Protein Alignment pyd and dlg1a

DIOPT Version :9

• Sequence 1: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Sequence 2: XP_005165955.1
• Gene: dlg1a / 114446
• ZFINID: ZDB-GENE-010724-8
• Length: 935
• Species: Danio rerio
• Alignment Length: 905
• Identity: 211/905 - (23%)
• Similarity: 350/905 - (38%)
• Gaps: 287/905 - (31%)

  Fly   223 LLETASTHSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVL 287
            ::.|.|..||.    :..|....:||..:.:.| ...|.|.:::||.||||... ||||.::.::
Zfish   208 VVNTESLDSSP----YVNGTEADYEYEEITLER-GNSGLGFSIAGGTDNPHIGE-DPSIFITKII 266

  Fly   288 KGGPA--EDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNP--------- 341
            .||.|  :.||:|||.|:.||.|.:.:|.::.||:.|:::|..|:|.|:||.||:.
Zfish   267 PGGAAAQDGRLRVNDCILRVNDVDVRDVTHSNAVEALKEAGCIVRLYVRRRKPLSEKIMDVKLVK 331

  Fly   342 ------INAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVT 400
                  .:.||.|.:||....:|:.:.....||.|
Zfish   332 GPKGLGFSIAGGVGNQHIPGDNSIYITKIIEGGAA------------------------------ 366

  Fly   401 LTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQE---GDIITRIHNTNCGDTMSLKEAK 462
             .|.|:     :.:|.:|            |..|...|:|   .|.:..:.||  .|.:.||.||
Zfish   367 -HKDGR-----LQIGDKL------------LAVNAVCLEEVTHEDAVAALKNT--PDVVYLKVAK 411

  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLP 527
            .                       :.:.:|:|         ||  .|.|:  ||.:.::|:
Zfish   412 P-----------------------TSVFMNDS---------YA--PPDVT--SSYSQHMEN---- 436

  Fly   528 GGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGR 592
               ..|:|:...||.|                                         |.||:|
Zfish   437 ---HISTQSYLSQPLT-----------------------------------------PATPSR-- 455

  Fly   593 SAAIDEPPRPPPPRGSSGGAAQEDFYS--SRRQLYEERQSAEPRFISFQKEGSVGI--RLTGGNE 653
                                     ||  |:..|.::..:.|||.|...: |:.|:  .:.||.:
Zfish   456 -------------------------YSPVSKGMLGDDEITREPRKIVLHR-GTTGLGFNIVGGED 494

  Fly   654 A-GIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEY 716
            . |||::.:..|.||.|.| |..||:|:.||.:|:...|.|:|...|.:....:.:|.||..|||
Zfish   495 GEGIFISFILAGGPADLCGELRKGDRIVSVNGVDLRSATHEQAAAALKNAGQTVTIIAQYRPEEY 559

  Fly   717 D-----------------------EVVTNQRGDSFHIKTHFHCD------NPSKGEMAFKAGDVF 752
            .                       .:.|:|: .:.:::..|..|      .||:| :.|:.||:.
Zfish   560 SRFEAKIHDLREQMMNSSISSGSGSLRTSQK-RTLYVRALFDYDITKDSGLPSQG-LNFRFGDIL 622

  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAE-----ELATAQFNATK--KEMNANESR 810
            .|::....   ..||...:....:..:.||||:|.|.|     .|.|.:||:..  |..:.|:.|
Zfish   623 HVLNASDE---EWWQARHVTTDGEMEEMGVIPSKKRVERKERARLKTVKFNSKSRDKAQSLNDKR 684

  Fly   811 GNFFRRRRSTHRRSKSLSRENWDDV------VFSDSISKFP-------AYERVVLRHPGFVRPVV 862
            ......|:....::|....:...||      ..|||.|.|.       :||.|..:...:.|||:
Zfish   685 RKTLFSRKFLFSKNKDTGEQETSDVDQHVTSNASDSESSFRGQEDYVLSYETVTQQEVSYSRPVI 749

  Fly   863 LFGPVSDLARERLAKDFPDKFST-------PLQD---------------------DDKSAATSGK 899
            :.||:.|...:.|..:|||||.:       |.:|                     .|.....:|:
Zfish   750 ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVNSREQMEKDIQDHKFIEAGQ 814

  Fly   900 CRI----VRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKA 960
            ...    ..:.::|:|.::|||.:||::.||:.||..||.||:.:|:|..|...|.::...|
Zfish   815 YNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQLAQLYPIAVFIKPKSVENILEMNKRL--- 876

  Fly   961 AHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKPVE 1020
            ..:..:|..::..|||:.:...|:..:.....|..|.:::..|:.|....:|:    ||:
Zfish   877 MEEQGRKTYDRAMKLEQEFLEHFTAIVQGDTLEEIYNQVKQIIEEQSGPFIWV----PVK 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	32/86 (37%)
		PDZ_signaling	396..477	CDD:238492	16/83 (19%)
		PDZ_signaling	633..710	CDD:238492	27/80 (34%)
		SH3_ZO	729..790	CDD:212793	17/66 (26%)
		GuKc	831..1007	CDD:214504	54/220 (25%)
		ZU5	2263..2351	CDD:279170
dlg1a	XP_005165955.1	L27_1	4..62	CDD:286187
		MAGUK_N_PEST	109..230	CDD:287565	6/25 (24%)
		PDZ_signaling	231..315	CDD:238492	32/85 (38%)
		PDZ_signaling	324..410	CDD:238492	23/135 (17%)
		PDZ_assoc	411..474	CDD:287558	24/173 (14%)
		PDZ	472..556	CDD:214570	30/84 (36%)
		SH3	588..661	CDD:302595	19/77 (25%)
		Guanylate_kin	744..922	CDD:279019	44/180 (24%)
		GuKc	755..922	CDD:214504	39/169 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910