DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and Magi2

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_446073.2 Gene:Magi2 / 113970 RGDID:621855 Length:1277 Species:Rattus norvegicus


Alignment Length:1438 Identity:263/1438 - (18%)
Similarity:414/1438 - (28%) Gaps:609/1438 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 TKPPKSNVYNPLVRYRPTAYVRNGIIGGAEGPGSSGVYQIADRVYTTSKMFLRDGYMYPRQPGQT 76
            |||.::...:||......||...|           .||.|.....|||                .
  Rat   293 TKPEENEDSDPLPDNWEMAYTEKG-----------EVYFIDHNTKTTS----------------W 330

  Fly    77 MDPRF-----PLE---LHEFPQQFGATGLQLVSAPKVHIAGEYLAS-------------EQQQQQ 120
            :|||.     |.|   .:|.|.     |.:.:..|   |.|.|...             |.:::.
  Rat   331 LDPRLAKKAKPAEECKENELPY-----GWEKIDDP---IYGTYYVDHINRRTQFENPVLEAKRKL 387

  Fly   121 QQQQQQHQQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRSITSCMGGGGGG 185
            ||....|.::                                                       
  Rat   388 QQHNMPHTEL------------------------------------------------------- 397

  Fly   186 GEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTTWEYHT 250
            |.|..:..|.|::|           |..||........|.|.          .||.:        
  Rat   398 GTKPLQAPGFREKP-----------LFTRDASQLKGTFLSTT----------LKKSN-------- 433

  Fly   251 VAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRIISVNGVSLENV 313
                    .|||..:.|| |.|     |..:.|..|:..|||  :.:::..|.|:.:|.|.:...
  Rat   434 --------MGFGFTIIGG-DEP-----DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484

  Fly   314 EYATAVQVLRD--SGNTVQLVVKRRVPL--NPINAAGAV-----------------QHQHSHSLS 357
            .:|..|::.:.  .|.:|.||:.|..||  :|.:.|.::                 :|.:...|.
  Rat   485 THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLE 549

  Fly   358 SVGLMANGSGGVAPTPITSL-----------SQPNSLNSSLVQNASSG----QPIKVTLTKGGKK 407
            .:...:.....:...|..||           :.|..::...|..||||    :.:.:|:.||.:.
  Rat   550 YISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAQG 614

  Fly   408 DDYGVVLGCRLFVKEISSKAREQLNANGY-SLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCK-- 469
                  .|..:.......:.::.|:..|. .|.|||:|..|:..|. ..:|..|...|:..|.  
  Rat   615 ------FGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNV-QNLSHTEVVDILKDCPVG 672

  Fly   470 ERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYA---THQPQV---SGCSSSNNNLEDPYLPG 528
            ...:|::.|                      |..::   |.:|.|   ....|...:|..|.:| 
  Rat   673 SETSLIIHR----------------------GGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVP- 714

  Fly   529 GASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRS 593
                  |:|...|....|:.|:                           |.:..|          
  Rat   715 ------QSLPFPPALHRSSFPD---------------------------STEAFD---------- 736

  Fly   594 AAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGS--------------- 643
                  ||.|.|         .:.|...|.:||.||...|| .||:.:.|               
  Rat   737 ------PRKPDP---------YELYEKSRAIYESRQQVPPR-TSFRMDSSGPDYKELDVHLRRME 785

  Fly   644 --VGIRLTGGNEAG--IFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEAVLFLLSLQD 703
              .|.|:.||:|.|  |.:.||.....|...| |.|||:::.|:.:.:.|               
  Rat   786 SGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAG--------------- 835

  Fly   704 RIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQV 768
                                       |||.:                  |||.:|:........
  Rat   836 ---------------------------KTHRY------------------VIDLMHHAARNGQVN 855

  Fly   769 LKIGR-----GHQEMQRGVIP-------NKSRAEELATAQFNATKKEMNANESRGNFFRRRRST- 820
            |.:.|     |....:.|..|       :..|::....|..|......||:...| |......| 
  Rat   856 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSSNASPPEG-FASHSLQTS 919

  Fly   821 ----HRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSD-LARERLAKDFP 880
                ||:    ..|.:..|:.| |:::..:...:.:.|.        .|.:.| ...:|.||   
  Rat   920 DVIIHRK----ENEGFGFVIIS-SLNRPESGATITVPHK--------IGRIIDGSPADRCAK--- 968

  Fly   881 DKFSTPLQDDDKSAATSGKCRIVRLSN---IRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFL 942
                  |:..|:..|.:|: .|:.:.:   ::.:.|.|....|.|.|.  :.||           
  Rat   969 ------LKVGDRILAVNGQ-SIINMPHADIVKLIKDAGLSVTLRIIPQ--EELN----------- 1013

  Fly   943 KTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQ 1007
                          .|.:|..|.|                   |..::.:.|       .:..|.
  Rat  1014 --------------SPTSAPSSEK-------------------QSPMAQQHS-------PLAQQH 1038

  Fly  1008 SGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSL----GNLPQLVKASS 1068
            |.....|.:.|                    :||.:    .|.|...|.|    .:....|||..
  Rat  1039 SPLAQPSPATP--------------------NSPVA----QPAPPQPLQLQGHENSYRSEVKARQ 1079

  Fly  1069 D--PSIATNQDNLDRDRDIIGEGLPPPYT----VPYDHAVP-----ANPN----RRQTMDSSKYS 1118
            |  |.|.                 .||:|    .|.|:..|     :.|:    |:.:.|:.:|.
  Rat  1080 DVKPDIR-----------------QPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYP 1127

  Fly  1119 IYGTNVPPQ------QQQPGVGGDTAAVR-----PQSLYGIN-APDLPPRIDRQSKPGDIPLNTS 1171
            :.....|..      ..:.|..|...::|     ...||.:. |.|.|...:.:.:.||..:..:
  Rat  1128 LSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEIN 1192

  Fly  1172 GSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQAR 1236
            |.|:|:.|..|:.:                      |:.||.                   |:.|
  Rat  1193 GESTRDMTHARAIE----------------------LIKSGG-------------------RRVR 1216

  Fly  1237 LNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQN----------LGRLGPNAPDDLKSVPN 1291
            |  .||     .|.|....|..|.|     :..|.|::          ||.     |.|..: |.
  Rat  1217 L--LLK-----RGTGQVPEYGMVPS-----SLSMCMKSDKHGSPYFYLLGH-----PKDTTN-PT 1263

  Fly  1292 ANGRPLPP 1299
            ....||||
  Rat  1264 PGALPLPP 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 23/88 (26%)
PDZ_signaling 396..477 CDD:238492 18/83 (22%)
PDZ_signaling 633..710 CDD:238492 22/96 (23%)
SH3_ZO 729..790 CDD:212793 13/72 (18%)
GuKc 831..1007 CDD:214504 27/179 (15%)
ZU5 2263..2351 CDD:279170
Magi2NP_446073.2 PDZ_signaling 22..96 CDD:238492
GuKc 118..291 CDD:214504
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..308 5/14 (36%)
Interaction with DDN. /evidence=ECO:0000250 302..381 23/113 (20%)
WW 304..333 CDD:395320 10/55 (18%)
WW 350..381 CDD:197736 6/38 (16%)
PDZ 428..509 CDD:214570 25/112 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 3/18 (17%)
PDZ 602..683 CDD:214570 19/109 (17%)
MAGI_u5 687..758 CDD:406953 23/129 (18%)
PDZ 775..861 CDD:214570 25/145 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..913 9/44 (20%)
PDZ_signaling 920..1007 CDD:238492 20/109 (18%)
PRK10263 <1007..>1135 CDD:236669 35/221 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1130 34/210 (16%)
PDZ_signaling 1140..1220 CDD:238492 21/122 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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