DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and Scrib

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_598850.1	Gene:	Scrib / 105782	MGIID:	2145950	Length:	1665	Species:	Mus musculus

Alignment Length:	1247	Identity:	249/1247 - (19%)
Similarity:	411/1247 - (32%)	Gaps:	377/1247 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 EKERERGGDRDRPYIRNVDDLLQALG-----KRDGGDNNSNLL-ETASTHSSSQRRRFKKGDRTT 245
            |:|.|...:.:.......||..:|:.     |....|..:||| |.|               |..
Mouse   660 EEEEENRDEEEGEATTEEDDKEEAVASAPSVKGVSFDQANNLLIEPA---------------RIE 709

  Fly   246 WEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGP-AEDRLQVNDRIISVNGVS 309
            .|..|:.:.|..| |.||:::||:.:..:...|..|.:|.|.:.|| |...::|.|:::.||||:
Mouse   710 EEELTLTIVRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVA 773

  Fly   310 LENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPI 374
            |::.|:..||:.||.:|..||:.|.|...:.|.||......:.....|.    ....||....|:
Mouse   774 LQDAEHHEAVEALRGAGAAVQMRVWRERMVEPENAVTITPLRPEDDYSP----REWRGGGLRLPL 834

  Fly   375 TSLSQPNSL---NSSLVQNASSGQPIKVTLTKGG---KKDDYGVVLGCRLFVKEISSKAREQLNA 433
            .....|.||   :::.:..:..|....:...||.   :..|.|:      |:..|:......
Mouse   835 LQPETPVSLRQRHAACLVRSEKGLGFSIAGGKGSTPYRAGDGGI------FISRIAEGGAAH--- 890

  Fly   434 NGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQ 498
            ...:||.||.:..|:..:..:... ..|..::......::|::.|: |..|.......::|.:..
Mouse   891 RAGTLQVGDRVLSINGVDMTEARH-DHAVSLLTAASPTISLLLERE-TGGTYPPSPPPHSSPTPA 953

  Fly   499 ASGNIYATHQPQVSG--------CSSSNNNLEDPY------LP-----------GGASYSSQNLY 538
            |:  :.||....|.|        .|.....||.||      ||           ||:.:||....
Mouse   954 AT--VAATVSTAVPGEPLLPRLSPSLLATALEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFG 1016

  Fly   539 VQPPTRTSNGPNINGNGLNDEKSNLTPRGRSR------GPIMDGVSLQQLDRPVTPTRGRSAAID 597
            ||.|     |..|         |.:.|||.:.      |..:..|:.|.: |..|.....||.:
Mouse  1017 VQDP-----GVFI---------SKVLPRGLAARCGLRVGDRILAVNGQDV-REATHQEAVSALL- 1065

  Fly   598 EP--------PRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGG--- 651
            .|        .|.|||.|             .|:|..::...|          .:||.:.||
Mouse  1066 RPCLELCLLVRRDPPPPG-------------MRELCIQKAPGE----------KLGISIRGGAKG 1107

  Fly   652 --------NEAGIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDL 707
                    .:.|||::.|.|...|...| |..|.::|:||...:.|:|..|||..|.|:.|.:.:
Mouse  1108 HAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHAEAVQLLRSVGDTLTV 1172

  Fly   708 IVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDT-------LHNGVVGS 765
            :|                          ||.                .||       :..||:.:
Mouse  1173 LV--------------------------CDG----------------FDTSTTTALEVSPGVIAN 1195

  Fly   766 WQVLKIGRGHQ-------EMQRGVIP-NKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHR 822
              ....|.||:       .:.|.:.| ...:.:|||:   .|...|..:.|:.|......:..:|
Mouse  1196 --PFAAGLGHRNSLESISSIDRELSPEGPGKEKELAS---QALPWESESAETTGRNLEPLKLDYR 1255

  Fly   823 RSKSL----SRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKF 883
            ...:|    |.:...........::.|.........||.::|              ||:.:|...
Mouse  1256 ALAALPSAGSLQRGPSATTGGKTTEAPCSPGSQQTKPGVIQP--------------LAQAWPRNS 1306

  Fly   884 STPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRL--NYAQFYPVVIFLKTDS 946
            ..|       ....|.|                      :|.:.|.|  |..|.|..  |....:
Mouse  1307 PAP-------RGRGGPC----------------------SPPSPDELPANVKQAYRA--FAAVPT 1340

  Fly   947 KHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKL----RDSIDLQQ 1007
            .|..:......|.....:|.   ||....||  ...|..::.:...|...:::    .|.:...|
Mouse  1341 VHPPENSATQPPTPGPAASP---EQLSFRER--QKYFELEVRVPQAEGPPKRVSLVGADDLRKMQ 1400

  Fly  1008 SGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSI 1072
            .......:.|..:.|.::                    .::.||                 |..:
Mouse  1401 EEEARKLQQKRAQMLREE--------------------AVTSGP-----------------DMGL 1428

  Fly  1073 ATNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDT 1137
            |:::::.|..::     ...|:.|| .||..::|:                     ..|.:||:.
Mouse  1429 ASDRESPDDQQE-----AEQPWAVP-SHAGGSSPS---------------------SPPPLGGNA 1466

  Fly  1138 ------AAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQD 1196
                  |..|.|....:.:|:||.. :|...|.:    .....:....|.|:|:.    |::.||
Mouse  1467 PVRTAKAERRHQERLRMQSPELPAP-ERALSPAE----RRALEAEKRALWRAARM----KSLEQD 1522

  Fly  1197 DVQAEYITRNALVGSGAAETLDRQQQQQQ---------------QTHASLERQARLNAQLKANGV 1246
            .::|:.:...:..|.|....|:|..:...               ||.||..|......:......
Mouse  1523 ALRAQMVLSKSQEGRGKRGPLERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLPLSGKKFDYRAF 1587

  Fly  1247 GAGGGGASTYD---------------SVSSYDSYNNTQMAMQNLGRLGPNA--PDDL------KS 1288
            .|.......||               |.|......:.::|:..|||..|.|  |:|:      :|
Mouse  1588 AALPSSRPVYDIQSPDFVEELRTLEASPSPGSQEEDGEVALVLLGRPSPGAVGPEDMTLCSSRRS 1652

  Fly  1289 V-PNANG-RPLP 1298
            | |...| .|:|
Mouse  1653 VRPGRRGLGPVP 1664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	30/85 (35%)
		PDZ_signaling	396..477	CDD:238492	13/83 (16%)
		PDZ_signaling	633..710	CDD:238492	24/88 (27%)
		SH3_ZO	729..790	CDD:212793	11/75 (15%)
		GuKc	831..1007	CDD:214504	27/181 (15%)
		ZU5	2263..2351	CDD:279170
Scrib	NP_598850.1	LRR_RI	12..232	CDD:238064
		leucine-rich repeat	14..37	CDD:275380
		leucine-rich repeat	38..60	CDD:275380
		LRR	39..405	CDD:227223
		leucine-rich repeat	61..83	CDD:275380
		leucine-rich repeat	84..106	CDD:275380
		leucine-rich repeat	107..129	CDD:275380
		leucine-rich repeat	130..152	CDD:275380
		leucine-rich repeat	153..175	CDD:275380
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..221	CDD:275380
		leucine-rich repeat	268..290	CDD:275380
		LRR_4	289..329	CDD:289563
		leucine-rich repeat	291..313	CDD:275380
		leucine-rich repeat	314..336	CDD:275380
		leucine-rich repeat	360..381	CDD:275380
		PDZ	711..799	CDD:214570	32/88 (36%)
		PDZ_signaling	854..933	CDD:238492	14/88 (16%)
		PDZ_signaling	988..1076	CDD:238492	23/103 (22%)
		PDZ_signaling	1085..1175	CDD:238492	28/125 (22%)
		AbLIM_anchor	1565..>1659	CDD:292800	21/93 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910