DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and LOC103911473

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_009302062.1	Gene:	LOC103911473 / 103911473	-ID:	-	Length:	794	Species:	Danio rerio

Alignment Length:	937	Identity:	269/937 - (28%)
Similarity:	414/937 - (44%)	Gaps:	233/937 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 SYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGR-SRGPIMDGVSLQQLDRPVTPTRGRSA 594
            |||.|:   ...:|.|:..:.:.|.:..|.:...|:.| ::.|:... ..:.::.|......|..
Zfish     6 SYSPQD---DQRSRQSDLSSHSSNDVARENTREDPQSRLTKSPVTSS-PYKTVEEPHPAQEERVE 66

  Fly   595 AIDEPPRPPPP-------------RGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGI 646
            ..||.|.||||             |.|   ...|..|.....:           :||||..|||:
Zfish    67 PQDEEPPPPPPPPPAIKMTPKILLRPS---PEDEAIYGPNTVM-----------VSFQKGESVGL 117

  Fly   647 RLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQ--DRIDLIV 709
            ||.|||:.|||:..||.||||..:||..||:|:|||::|..|:.|||||||||.:.  :.:.::.
Zfish   118 RLAGGNDVGIFIAGVQEGSPAEEEGLRVGDQIMKVNNVDFRGIVREEAVLFLLEIPRGEVVTILA 182

  Fly   710 QYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRG 774
            |...|.|::::.:.|||||.|:|||..:.......||..|::|:|:|||::|.:|:|..:::|:.
Zfish   183 QSKTEVYEDILVSGRGDSFFIRTHFEYEKELPQCHAFSRGEIFKVVDTLYDGKLGNWLAIRLGKD 247

  Fly   775 HQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSL--SRENWDDVVF 837
            :|.:::|:||||||||::|..| |..|   .....|.:|:|.|.....:.|.|  |||.....|
Zfish   248 NQLLEKGIIPNKSRAEQMANVQ-NTHK---GTGSDRADFWRLRGQRAAKKKDLRKSREESSAAV- 307

  Fly   838 SDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRI 902
               .::||||||||||..||.||||||||::|.|.|:||.:.||:| ...:.:.|.|.:.....:
Zfish   308 ---ATRFPAYERVVLREAGFRRPVVLFGPIADAASEKLASELPDEF-VIAKTEPKDAGSEKSSGV 368

  Fly   903 VRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKK 967
            |||:.||.::::.||||||:||.|||.|||.|:||:|||...||||.:|.:|..:..::::|::|
Zfish   369 VRLNTIRQIIEQDKHALLDVTPKAVDTLNYTQWYPIVIFFNPDSKHGVKAMRQRVIPSSNRSARK 433

  Fly   968 LLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMSESKPVESLSDD------ 1025
            |.:|..||.:..||:|:..|.| |..::||..|:::|..|||.|||:||.| ::....|
Zfish   434 LYDQALKLRKTCSHLFTAVIDLNSANDAWYGSLKEAIREQQSLAVWVSEGK-LDGTEGDLDVHDD 497

  Fly  1026 ---FLFPMTTSRLSYASSPESDLE-----------------LSPGPSASLSLGN---LPQLVKAS 1067
               :|..|:...||..|...||.:                 |.....:::|..:   :|:.:...
Zfish   498 RMSYLSAMSADYLSMDSRMTSDYDDTADEGGTYTDNETDEPLDRQRVSAISRSSEPVMPEEILRK 562

  Fly  1068 SDPSIA-------TNQDNLDRDRDIIGEGLPPPYTVP-----------------YD--HAVPANP 1106
            |.|.|.       :.:...|....::...||.|..|.                 ||  .:.||:.
Zfish   563 SSPEIRGRTRRKNSREKTSDCSPPVMSTFLPDPAKVKMLSQVEVSRGHYDPSRNYDSRSSSPASS 627

  Fly  1107 NRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTS 1171
            ..::::||           |.:.:|       |..|..|    .|.|..|..|.....:.|.::.
Zfish   628 EHQRSLDS-----------PAKAKP-------APPPTPL----KPALASRSSRGLINSEPPADSP 670

  Fly  1172 GSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQAR 1236
            ...|:...||:           |:...|.::..|:..|                     ||.|..
Zfish   671 EDPSKRSFLGK-----------VKAFEQMDHFARSQRV---------------------LEIQEA 703

  Fly  1237 LNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPD----DLKSVPNANGRPL 1297
            .||:|:                                   :....||    .:||....:.||.
Zfish   704 QNARLE-----------------------------------IAQKHPDIYAVPMKSQKLDHSRPQ 733

  Fly  1298 PPTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSP- 1361
            |....:....:||                 |.:..|.:..|                |||...|
Zfish   734 PIGSSARPEPQTP-----------------PSKLPYTESRA----------------LGLSEEPV 765

  Fly  1362 ---RKPLVETKTDYGKYSRNNSVTQAD 1385
               |:.|.| ::..|.|:.::|....|
Zfish   766 EEFRQQLTE-QSKRGYYTSSSSQKYQD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	40/78 (51%)
		SH3_ZO	729..790	CDD:212793	24/60 (40%)
		GuKc	831..1007	CDD:214504	78/176 (44%)
		ZU5	2263..2351	CDD:279170
LOC103911473	XP_009302062.1	PDZ_signaling	104..181	CDD:238492	40/87 (46%)
		SH3_ZO-2	198..263	CDD:212960	28/64 (44%)
		GuKc	307..474	CDD:214504	78/171 (46%)
		Guanylate_kin	325..473	CDD:279019	65/148 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010