DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and USH1C

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens

Alignment Length:	825	Identity:	167/825 - (20%)
Similarity:	270/825 - (32%)	Gaps:	278/825 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 QHQQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRSITSCMGG---GGGGGE 187
            :||  .|..||..|::....|:.|             .|.....:|    .|..||   |.|...
Human    69 KHQ--VEYDQLTPRRSRKLKEVRL-------------DRLHPEGLG----LSVRGGLEFGCGLFI 114

  Fly   188 KERERGGDRDRPYIRNVDDLLQALGKRDGGDNNS---NLLETASTHSSSQRR------RFKKGDR 243
            ....:||..|...::..|::::..|.......:.   ||:.|..|.|...|.      :....:.
Human   115 SHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEP 179

  Fly   244 TTWEYHTVAVTRVPGYGFGIAVSGGRDNPH----------------FANG---DPSIAVSDVLKG 289
            .||:|....|:...|....:...|.|:|..                .::|   .|.|.:|.|..|
Human   180 LTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPG 244

  Fly   290 G-PAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTV------------------------ 329
            . .||..|::.|:|:.||||...|:::..||.||:.|.:..
Human   245 SLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQ 309

  Fly   330 ------QLVVKRRVPLNP---INAAGAVQHQHSHSLSSVGLMAN--------------------- 364
                  :|::::|:.:..   :.....::.|....::......|
Human   310 RELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQW 374

  Fly   365 ----GSGG--VAPTPITSLSQPNSLNSSLVQNASSGQPIKV-----TLTKGG---KKDDYGVVLG 415
                ||..  :.|..||:...|..|.    :..|.|...:.     |:.|.|   ||..||.:..
Human   375 EEDWGSKEQLLLPKTITAEVHPVPLR----KPKSFGWFYRYDGKFPTIRKKGKDKKKAKYGSLQD 435

  Fly   416 CRLFVKEIS-----SKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLV 475
            .|...||:.     .|.:|::......|:...:...:..|...|   |:|::| |....|||
Human   436 LRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERED---LEESEK-IQYWVERL--- 493

  Fly   476 VLRDITNQTAVSQL-NLNNSASHQASGNIYATHQPQVS-----------GCSSSNNNLEDPYLPG 528
                  .||.:.|: :.:|..|...:|.  ....|.||           |......:|:|  :|.
Human   494 ------CQTRLEQISSADNEISEMTTGP--PPPPPSVSPLAPPLRRFAGGLHLHTTDLDD--IPL 548

  Fly   529 GASY----SSQNLYVQPPTRTSNGPN---------INGNGLNDEKSNLTPRGRSRGPIMDGVSLQ 580
            ...|    :...|.|.|....||.|:         ::|: ::...|....|.....||....|:.
Human   549 DMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVLPLSGH-VSASSSPWVQRTPPPIPIPPPPSVP 612

  Fly   581 QLDRPVTPTRGRSAAIDEP---------------------------------------------P 600
            ..|  :||||...:|::|.                                             |
Human   613 TQD--LTPTRPLPSALEEALSNHPFRTGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCP 675

  Fly   601 RPPPPRGSSGG--------------------------------------AAQEDF--YSSRRQLY 625
            .|.||||....                                      |.::||  |......|
Human   676 SPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDPY 740

  Fly   626 -----EERQSAEPRFISFQKEGSVGIRLTGGNEAGI---FVTAV-QPGSPASLQGLMPGDKILKV 681
                 |:....:.|.:..:||||:.:.|.||.::.|   .|:|| :.|:.....|::.||:|:.:
Human   741 SMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAI 805

  Fly   682 NDMDMNGVTREEAVLFLLSLQ-------DRIDLIVQYC-KEEYDE 718
            |...:...|..||.   .:||       |.|||:|..| .:|||:
Human   806 NGKIVTDYTLAEAE---AALQKAWNQGGDWIDLVVAVCPPKEYDD 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	27/134 (20%)
		PDZ_signaling	396..477	CDD:238492	22/93 (24%)
		PDZ_signaling	633..710	CDD:238492	27/87 (31%)
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
USH1C	XP_016872564.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910