DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and mpp4a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_009302812.1	Gene:	mpp4a / 100535324	ZFINID:	ZDB-GENE-070912-523	Length:	627	Species:	Danio rerio

Alignment Length:	495	Identity:	104/495 - (21%)
Similarity:	175/495 - (35%)	Gaps:	164/495 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 QSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLM-PGDKILKVNDMDMNGVTRE 692
            ::.:|...:.:|:...|         .||:..|..|..|...||: .|||:::||...:.|:..|
Zfish   154 KNKQPLGATIRKDEKTG---------NIFIARVIHGGLADRSGLLNSGDKLVEVNGQKVRGMQPE 209

  Fly   693 EAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHF---------------HCDNPSKG 742
            ..:..|:..|..|          ..:|:.|....:....|.:               .|  |..|
Zfish   210 HVINILVRSQGNI----------LFKVIPNSTQPTNSQATLYVRAMVDYSPLQDPAIPC--PDVG 262

  Fly   743 EMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQ-EMQRGVIPNKSR------------------ 788
             |||..||:..::|...   :..||..|:   |. .:..|:||:.::
Zfish   263 -MAFSKGDLLEIVDQRD---IRWWQARKL---HSASLCCGLIPSTNQFRHKQRELWWSQPYQAHT 320

  Fly   789 ----------AEELATAQFNATKKE-----------MNANESRGNF---FR------RRRSTHRR 823
                      .||..|.:...|:.:           .|....:|.:   ||      ||:|..:|
Zfish   321 CIRPLSADDVGEEEITDKIKCTETDEEDFEFVSEEGENGEHMQGLYIAGFRHSLRVWRRKSYSKR 385

  Fly   824 SKSLSRENWDDVVFSDSIS-----KFPAYERVV--LRH----PGFVRPVVLFGP----VSDLARE 873
            ..|         .:|.|||     ....||.||  .||    |   |.:||.||    |::| |.
Zfish   386 KPS---------CYSCSISSCHNTSANLYEEVVHYQRHIDDPP---RLIVLIGPSGVGVNEL-RR 437

  Fly   874 RLAKDFPDKFSTPL-------QDDDKSAAT------------------------SGKCRIVRLSN 907
            ||.|..|:.:..|:       ...:|:...                        :|......|.:
Zfish   438 RLIKINPNTYQGPVSYTTRPQNMGEKNGREYHFVTKEVFAYMVVNHKFYEYEEHNGHMYGTSLDS 502

  Fly   908 IRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQC 972
            ::||:|.||..::||.|:.:..:......|.:|:::..|...::|.|......|::..|:...
Zfish   503 VKDVLDNGKICVIDIEPHCIQSVRNKMLKPYIIYVRPPSPEGMRQTRKDPHFLANRYIKRYFH-- 565

  Fly   973 QKLERVWSHIFSTQIALSDEESWYRKLRDSI----DLQQS 1008
               ::.:..|.....|:   |:.||:..|.:    |||.|
Zfish   566 ---DKDFEDIEDVSRAM---EAKYRQFFDCVIVNEDLQDS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	20/77 (26%)
		SH3_ZO	729..790	CDD:212793	17/104 (16%)
		GuKc	831..1007	CDD:214504	50/225 (22%)
		ZU5	2263..2351	CDD:279170
mpp4a	XP_009302812.1	L27	24..76	CDD:197794
		L27	84..133	CDD:308467
		PDZ	147..230	CDD:214570	21/94 (22%)
		SH3	241..300	CDD:327375	16/67 (24%)
		Guanylate_kin	419..610	CDD:331880	42/193 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910