DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and tjp1

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_031755020.1 Gene:tjp1 / 100498413 XenbaseID:XB-GENE-490684 Length:1830 Species:Xenopus tropicalis


Alignment Length:2312 Identity:610/2312 - (26%)
Similarity:927/2312 - (40%) Gaps:646/2312 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 RPYIRNVDDLLQALGKRDGGD----NNSNLLETASTHSSSQRRRFKKGDRTTWEYHTVAVTRVPG 258
            :|.:|.:...:......|..|    ||:.:.|||                 .||..||.:.|.||
 Frog    51 KPSLRRIKGRIHRSKSLDSVDLCDFNNTVMEETA-----------------IWEQQTVTLHRAPG 98

  Fly   259 YGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLR 323
            :|||||:|||||||||.:|:.||.:||||||||||..||.|||:..|||||::|||:|.|||.||
 Frog    99 FGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGLLQENDRVAMVNGVSMDNVEHAFAVQQLR 163

  Fly   324 DSGNTVQLVVKRR-------VPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPIT-----S 376
            .||...::.::|:       |..:|...:...:..:...:.......:|.|....:..:     |
 Frog   164 KSGKNAKITIRRKKKVQLPVVRSDPDPVSENEEDSYEEDVPDQRSAHSGPGASRRSEKSWVRDRS 228

  Fly   377 LSQPNSL----NSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYS 437
            .|:..||    :...|.::...:|.||||.|..|.::||:.|...:||||||   ::.|.|...:
 Frog   229 ASRERSLSPRSDRRSVSSSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEIS---QDSLAARDGN 290

  Fly   438 LQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRD-------------------ITNQ 483
            :||||::.:|:.| ..:.|||.:||.:|:..|.:|.:||.||                   .:.:
 Frog   291 IQEGDVVLKINGT-VTENMSLADAKTLIERSKGKLKMVVQRDERATLLNVPDLDDSLHSANASER 354

  Fly   484 TAVSQL-----------------NLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYL--PGG 529
            ..:|::                 :.:.|...::..:.::.|.||....|||.:. ||..:  ||.
 Frog   355 DDISEIQSLTSDHSNRSHDKPRRSRSRSPDQRSEPSDHSRHSPQQHSNSSSRSR-EDERVSKPGA 418

  Fly   530 ASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSA 594
            .|...:|:...|.:||:..|.:      ::....||......|:........:|.||:|:.|   
 Frog   419 ISTPVKNVNSVPLSRTAEEPFL------EKADKQTPPLPEPKPVYAQPGQPDVDLPVSPSDG--- 474

  Fly   595 AIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVT 659
                   |.|......|..:...                :.:.|:|..|||:||.|||:.||||.
 Frog   475 -------PFPNSTHEDGMLRPSM----------------KLVKFRKGDSVGLRLAGGNDVGIFVA 516

  Fly   660 AVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQ--DRIDLIVQYCKEEYDEVVTN 722
            .|...|||:.:||..||:||:||::|...:.|||||||||.|.  :.:.::.|..|:.|..:|.:
 Frog   517 GVLDDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVES 581

  Fly   723 QRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKS 787
            ..||||:|:|||..:..|...::|..|:||||:|||:||.:|||..::|||.|:|::||:||||:
 Frog   582 DVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGRNHKEVERGIIPNKN 646

  Fly   788 RAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVL 852
            |||:||:.|:...|   .|...|.:|:|.|..  |.||...|::.:|:......:||||||||||
 Frog   647 RAEQLASVQYTLPK---TAGGDRADFWRFRGL--RSSKRNLRKSREDLSAQPVQTKFPAYERVVL 706

  Fly   853 RHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKH 917
            |..||:||||:|||::|:|||:||::.||.:.....:...:........|:||..|:.::||.||
 Frog   707 REAGFLRPVVIFGPIADVAREKLAREEPDIYEVARSEPRDAGTDQRSSGIIRLHTIKQIIDRDKH 771

  Fly   918 ALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHI 982
            ||||:||||||||||||:||:|:||..|||..:|.:|..|...:.||::||.|:..||.:...|:
 Frog   772 ALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHL 836

  Fly   983 FSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLE 1046
            |:|.|.| |..:.||..|:::...||:..||:||.|......||  ..:...||||.|:|.|:..
 Frog   837 FTTTINLNSMNDGWYGGLKEAAQQQQNQLVWVSEGKAEGGTDDD--LDLHDDRLSYLSAPGSEYS 899

  Fly  1047 LSPGPSASLSLGNLPQLVKASSDPSIATNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQT 1111
            :                  .|:|....::.::.|.      ||  ..||             .|.
 Frog   900 M------------------YSTDSRHTSDYEDTDT------EG--GAYT-------------DQD 925

  Fly  1112 MDSSKYSIYGTNVPPQ-----QQQPGVGGDTAAVRPQSLYGINAPDLPPR-IDRQSKPG--DIPL 1168
            :|.:.....||  ||:     ..:| |..||:.::....|    |..||: |.|...||  ::| 
 Frog   926 LDETLNDEAGT--PPESAITRSSEP-VREDTSGMQENPAY----PTYPPQPILRTDSPGYKNVP- 982

  Fly  1169 NTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLER 1233
                           :|::                          ||.|.               
 Frog   983 ---------------SQQK--------------------------AEALP--------------- 991

  Fly  1234 QARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLP 1298
                               |:.|.||||..::..:..|:..:..|.....:|....|.::     
 Frog   992 -------------------AAPYLSVSSETNHTTSTAAVNPMVNLNNVRLEDPNHAPYSS----- 1032

  Fly  1299 PTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRK 1363
                          ::|.||   |.|..|....|         |..|:   |.||:|.::     
 Frog  1033 --------------YQSQGG---LLRSPSTEAAH---------IILRD---QEPSSLPVQ----- 1063

  Fly  1364 PLVETKTDYGK--YSRNNSVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKP 1426
              :::...|.|  |:...:..| :|....:...|.:......:|    :|..|.|:.        
 Frog  1064 --IDSAKVYRKEAYAMEENPRQ-NYLMKQQVLGHQIQRHEKETN----LNYDGVPAY-------- 1113

  Fly  1427 VPPPKPKNYRPPVQSGGSSGSGGTTPWENGDSGSPRSPNGFYYPPTPSH-----HHYGQQATPGS 1486
              ..||.| |...||                         :.|..|..:     |:|..:..   
 Frog  1114 --AEKPLN-REYDQS-------------------------YCYDSTSDYVDQFPHNYDSRIN--- 1147

  Fly  1487 PSNGHMQPPPPQQQQPTYGGSNGNYGQAPPPQSYPQANGYNGNGH-------HYNGGSGTGPYIA 1544
             .:.|:         |||....|.|..   .|||||...::...:       |.:.......:..
 Frog  1148 -FDDHV---------PTYDEQWGYYDD---KQSYPQRPPFDSKRNRDFNIRQHSDENLERNYFQQ 1199

  Fly  1545 PHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMSEMEPYD--ERY 1607
            |....|||:                 :.:.|....:.|:..|:      |:..|....||  .||
 Frog  1200 PRLEEPPPV-----------------AYDNRPRPSQNYKPTQV------HYEDSTTAEYDMHMRY 1241

  Fly  1608 DDYYNMPPPAAHPSQGHHMQRSRSAPRYPHERPPHAQDPNYYGHYGTSRGHSQPRQQYSQHHQQQ 1672
                 .|.|...||    :..|:|:...|           |:..:  .||:.....|.......|
 Frog  1242 -----KPEPQTIPS----VPTSKSSDAKP-----------YFDQH--IRGYEHSPTQVFNTKPGQ 1284

  Fly  1673 YYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLKSTRPLRRMNSMVEP---ERKPKGLRRQQ 1734
            |.....:|..||  ||.:.|..:|.:           |::||......|.|   |.......:.|
 Frog  1285 YDTSPRMEAMPP--PPVQSKPELLST-----------SSKPLPAPAPSVAPAATEEDDDPAMKPQ 1336

  Fly  1735 SMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQDAYYQRGGHYAPQQQEMMNSTYQNLE 1799
            |:|.|               ....|.....||.......|:...:....||              
 Frog  1337 SVLTR---------------VKMFENKRSNQGEKNKDINDSTLVKAPDVAP-------------- 1372

  Fly  1800 GEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLERRQAEAAAASGGRNGRRIVRRHSTT 1864
                                                                   :.|:.:.|.|
 Frog  1373 -------------------------------------------------------KPILNQVSAT 1382

  Fly  1865 TADRGGNPGPPRRPMISPGYEQDPQEIYQTRNGAYMLPDQRR---APSSEVMTRRRFYPGAANEQ 1926
            .|          .|:  |.|:||        ...|.:|:.::   .|..:::....:.|....|.
 Frog  1383 KA----------APV--PHYDQD--------KATYRVPEPQKPQVKPPEDIIRANHYDPDEDEEY 1427

  Fly  1927 TEEEPLYQSRREMQRE---MQRNHLYQSKREMQERISQGKRDMEREFSPQSSSSQSEAS-NSEAI 1987
            ..::..|..||..::.   :..|.|.:..:..|                    |||:.| ||   
 Frog  1428 YRKQLSYFDRRSFEKPTPLLSGNILPEPAKPAQ--------------------SQSQLSFNS--- 1469

  Fly  1988 YQSRREAKESALKTRSQLRDQIYQTRREALDSMAEPIYVSKRGMGRPAPIYETREESILQSRENE 2052
            |.|:  .|.:.|:   .|...|.:.|.:.:     |...|.....:|:|:.           .|.
 Frog  1470 YPSK--GKPADLE---PLDRPINEKRYDPV-----PQVTSSNQYTQPSPVV-----------VNH 1513

  Fly  2053 TDEKKEKECKTEQIQVEINAQPEEQIEDSTLSRSDLQKSSDTVIENPARAPLVQDEVDDDEEEEV 2117
            :...|....:...:.||        :..||:|:.:...:.       |:..|.:   ..:.|:.|
 Frog  1514 STHTKHMHLEASSVSVE--------VPSSTVSKPEPPPTQ-------AKPTLFR---PSNREDTV 1560

  Fly  2118 QD----QRD-PAESSADQTEQPTAIENNLHNEGMVEQSQNDS---DDVFEAADKVSPLAPPPAPV 2174
            |.    |:. |.:|..:.|||........:|....:...|.:   :..||:......|.|..|.|
 Frog  1561 QSNFYPQKSFPEKSPVNGTEQAPKTVTPSYNRFTPKPYTNSARPFERKFESPKFNHNLLPNEAQV 1625

  Fly  2175 QPPTPRSGRAPFHISNILKRTAPPPS-SPIGDSCTSIETQYTS-----QASLPVGPPNATSTPFS 2233
            :|..|               |.|..| .|:..|.|||.::..|     :......|.|....|.:
 Frog  1626 KPELP---------------TKPQNSPQPVLKSNTSISSELDSISKQTENKSKYQPNNVNPVPKA 1675

  Fly  2234 SSMSLPIAGPVNNQPSANGRFPTLPREPSTSRGFFDSNGGTLADKLWHVSLQIPPGAIPAGVRQE 2298
            ..:| |.|...:::..|:       ...:|:||||:||||.|:.....||:.||.||||.|:.||
 Frog  1676 IPVS-PSALEDDDEDDAH-------TVVATARGFFNSNGGVLSSIETGVSIIIPQGAIPDGIEQE 1732

  Fly  2299 IYFTVSDPRMGQAVGGPPLDMENGETMLSPLVMCGPQGLEFLVPVTLNIPHCAGRTA-SLGLALK 2362
            |||.|.  |....:  ||||.|.|||:|||||||||.||:|:.||.|.:||||..|. ....|||
 Frog  1733 IYFKVC--RDNSIL--PPLDKEKGETLLSPLVMCGPHGLKFVKPVELRLPHCASMTPDGWSFALK 1793

  Fly  2363 ATDSEKNLHTEWDNIDLPSN----AAAHTVSVKVDHF 2395
            ::|:.......|.|..||.:    ..|:.|||.:|||
 Frog  1794 SSDTSSGDPKHWQNKSLPGDPNYLVGANCVSVLIDHF 1830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 53/84 (63%)
PDZ_signaling 396..477 CDD:238492 33/80 (41%)
PDZ_signaling 633..710 CDD:238492 37/78 (47%)
SH3_ZO 729..790 CDD:212793 31/60 (52%)
GuKc 831..1007 CDD:214504 80/176 (45%)
ZU5 2263..2351 CDD:279170 51/87 (59%)
tjp1XP_031755020.1 PDZ_signaling 90..174 CDD:238492 53/83 (64%)
PDZ 251..331 CDD:214570 34/83 (41%)
PDZ 493..569 CDD:395476 37/75 (49%)
SH3_ZO-1 585..649 CDD:212959 34/63 (54%)
GuKc 683..862 CDD:214504 81/178 (46%)
ZU5 1697..1796 CDD:395639 57/102 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 111 1.000 Domainoid score I6165
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 624 1.000 Inparanoid score I852
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1175136at2759
OrthoFinder 1 1.000 - - FOG0001438
OrthoInspector 1 1.000 - - otm47496
Panther 1 1.100 - - O PTHR13865
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1692
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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