DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and cytip

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_031749616.1	Gene:	cytip / 100487714	XenbaseID:	XB-GENE-1000173	Length:	361	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	81/381 - (21%)
Similarity:	118/381 - (30%)	Gaps:	121/381 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 PNINGNGLNDEKSNL-------TPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPR 606
            |.:..|.:|.::|:.       .|||.....:.                 ||.::.|
Frog    27 PQMCSNEINGKRSHFLARALATLPRGHKHAAMT-----------------RSNSLIE-------- 66

  Fly   607 GSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGN----EAGIFVTAVQPGSPA 667
             |||...|      ||.|...:|..|......|.     .:|...|    |...:|..|...||:
Frog    67 -SSGTGPQ------RRLLAVVKQDNETFGFEIQT-----YKLQHQNVHAYEMCTYVCRVHDNSPS 119

  Fly   668 SLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVV--TNQRGDSFHI 730
            |..||..||.:..||.:..:|.|.:|.|       |.|.....|.:   .|.|  |..|......
Frog   120 SRAGLKIGDMLKTVNGVCTDGFTHQETV-------DLIRASGNYLR---IEAVNGTKIRKSELEA 174

  Fly   731 KTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIP---------NK 786
            |..|     .|.:...|..::..|:......:.|:....||......:|..:..         ||
Frog   175 KLLF-----LKQDFREKWAELRTVLRKEQEIIYGTVDEQKIQEAMDSLQSKMFESPTASTSFLNK 234

  Fly   787 SRA----------------------------EELATAQFNATKK--------EMNANESRGNFFR 815
            .|.                            |:.|:..|:....        :.|...|:.:...
Frog   235 HRVSSGSSCKSRLSFMTDSSDDYLWQMSVFDEDSASEGFSRQSSIDEDTFYGKPNGISSKRSSLS 299

  Fly   816 RRRS---THRRSKSLSRENWDDVVFSDSISKFPAYER--VVLRH-----PGFVRPV 861
            |.||   |...|:|:| .|||.:.||:.....|...|  .:.:|     ||..|.|
Frog   300 RHRSISVTSSGSESMS-PNWDTLSFSNFFGTLPRKSRRGSIRKHFLKYIPGLHRSV 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	21/80 (26%)
		SH3_ZO	729..790	CDD:212793	12/97 (12%)
		GuKc	831..1007	CDD:214504	12/38 (32%)
		ZU5	2263..2351	CDD:279170
cytip	XP_031749616.1	PDZ_signaling	75..160	CDD:238492	26/99 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910