DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and whrn

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_012824768.2	Gene:	whrn / 100486736	XenbaseID:	XB-GENE-989669	Length:	996	Species:	Xenopus tropicalis

Alignment Length:	1176	Identity:	250/1176 - (21%)
Similarity:	391/1176 - (33%)	Gaps:	327/1176 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 MANGSGGVAPTPITSLSQP--NSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRL------ 418
            |.:.||.|..:|..|::|.  .|:|||...:.||               |.|.||...:
Frog     1 MNSESGPVHRSPGGSINQSFRGSINSSSCGSISS---------------DVGRVLSMNVRRLHGA 50

  Fly   419 FVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQ 483
            ..:.::.:.||||               :|   |   :.|..:::.:......|.| :||....:
Frog    51 LNRLLTDQEREQL---------------LH---C---LRLYHSRRNVCDLVRTLRL-ILRPQDQR 93

  Fly   484 TAVSQLNLNNSASHQASGNIYATHQPQVS----GCSSSNNNLED------PYLPGGASYSSQNLY 538
            .....|.|....|.|...:.|.:....:.    |.|..||.|.|      |.|||.|...|.::.
Frog    94 QLFPLLRLVIPRSDQLLFDQYTSEGLYLKDLSLGSSGYNNVLSDKVLGFSPQLPGPAPLFSTSVP 158

  Fly   539 VQPPTRTSNGPNINGNGLNDEKSNLTP-RGRSRGPIMDGVSLQQLDRPV--TPTRGRSAAIDEPP 600
            ...|...::.|     |.....|...| ...:..|.:.|:| .....||  ||...|      ||
Frog   159 GTAPAFNTSVP-----GAAPAFSTPLPGTAPAFSPPVTGIS-PAFSSPVLGTPLMHR------PP 211

  Fly   601 RPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNE--AGIFVTAVQP 663
            .|..|.|.|....:.:....|:...:..::.|          .:|..:.||.|  .||:|:.|:|
Frog   212 YPGAPPGFSNSPPRANPTEVRQVTLKRNRNQE----------GLGFSIRGGVEHGTGIYVSLVEP 266

  Fly   664 GSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSF 728
            ||.|..:||..||:|||.|...::.||..|||..|...|   .|::        .|:::.|....
Frog   267 GSLAEQEGLRVGDQILKANGRPLDRVTHAEAVKALRGSQ---KLVL--------SVLSSGRIPGG 320

  Fly   729 HIKTHFH--------CDNPSKGE-------------------MAFKAGDVFRVIDTLHNGVVGSW 766
            ||.:|.:        ..:|.:|.                   ...:.||..:|     |.|:|..
Frog   321 HISSHIYTWVDAHGRSVSPPRGPPHLQSPLLAGTEQEKRSHLQLLQEGDEKKV-----NLVLGEG 380

  Fly   767 QVL-KIGRGHQEMQRGV-IPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSR 829
            ..| .:.||..|...|: |....:..|..:|......:.::.|.|  :|.........|....||
Frog   381 SSLGLLIRGGAEYSLGIYITGVDKGSEAESAGLKVGDQILDINGS--SFLSIPHDEAVRILGSSR 443

  Fly   830 ENWDDVVFSDSISKFPAYERVV-------LRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPL 887
            .....|   ..:.:.|....:|       ..:.|...|....|.:||.:.:.|.|  |.....|
Frog   444 HLMMTV---RDVGRIPHARTIVDETQWLTSSYTGNGEPQPSLGTLSDTSSDSLVK--PVFCRGP- 502

  Fly   888 QDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQ 952
                    |..:..:..|.|...|:...|..||...|.......|.|.|
Frog   503 --------TGSQVTLSSLGNQTLVLLEEKARLLLTEPERSTMSYYLQQY---------------- 543

  Fly   953 LRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVW--MSE 1015
                  |..|.|       .|.|......:.:||..::...|...:||..| |.|..||:  :..
Frog   544 ------KDHHIS-------VQALIMAMFELLNTQAKVTATFSLLSELRSQI-LPQDLAVFDNLVL 594

  Fly  1016 SKPVESLSDDFLFPMTTSRLSY---ASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATNQD 1077
            .:.:||:........|.|.||.   .||.||...:|...:|...|..|..:::..:||..:::..
Frog   595 KREIESMKSRQRSGDTVSVLSQTLSTSSSESHQTVSTASTARERLLWLLDVMENGTDPEGSSDSR 659

  Fly  1078 NL------DRDRDIIGEGL--PPPY-TVPYDHAVPANPN-RRQTMDSSKYSIYGTNVPPQQQQPG 1132
            :|      |...|.:...|  ||.: ..|...||...|. |||..:.::....|::      |.|
Frog   660 SLTQTTLPDISLDDVNSLLEEPPNFQPAPPQSAVQNAPQLRRQGRERAQRPSSGSS------QSG 718

  Fly  1133 VGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDD 1197
            :.....:..|       :|.|||.....:.|          ||.|.:
Frog   719 LFFTVPSTNP-------SPPLPPLTSPPASP----------SSENSS------------------ 748

  Fly  1198 VQAEYITRNALVGSGA--AETLDRQQQQQQQTHASLERQARLN--AQLKANGVGAGGGGASTYDS 1258
             ||.|...::.:.|.:  ...|....|........::...||.  .::.::......|.||.
Frog   749 -QAIYTNHSSKITSPSLPPAQLALVTQHPLTPFPRVQSPTRLKVLGEIPSHPPSTTNGEASD--- 809

  Fly  1259 VSSYDSYNNTQ-MAMQNLGRLGPNA-PD--DLKSVPNANG-RPLPPTGQSHEYGRTPHDHRSFGG 1318
                   ||:| ..|..:.|  ||: ||  ::::||.... .||.|
Frog   810 -------NNSQHFVMVEVHR--PNSEPDVNEIRAVPQTRAVLPLSP------------------- 846

  Fly  1319 PNDLNRQSSPGRPHYHDMNASRNID--------PRNGTPQRPSNLGLESSPRKP-LVETKTDYGK 1374
            |..|::.|..|:    .::....:|        .::.:||.....|.|...:.| |:|
Frog   847 PASLSQLSDSGQ----TLSEDSGVDAGDVGGGGSKDSSPQPQKTKGCEGLQKPPGLLE------- 900

  Fly  1375 YSRNNSVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPV 1439
                   ..|...::.||||                 ..|.....|:...:|:|      ....:
Frog   901 -------PTATLVRVKKTAP-----------------SLGIAIEGGAKTRQPLP------RIVTI 935

  Fly  1440 QSGGSS 1445
            |.|||:
Frog   936 QRGGSA 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	13/86 (15%)
		PDZ_signaling	633..710	CDD:238492	28/78 (36%)
		SH3_ZO	729..790	CDD:212793	17/89 (19%)
		GuKc	831..1007	CDD:214504	35/182 (19%)
		ZU5	2263..2351	CDD:279170
whrn	XP_012824768.2	harmonin_N_like	40..117	CDD:416392	17/98 (17%)
		PLN02983	<144..>217	CDD:215533	22/84 (26%)
		PDZ_signaling	231..312	CDD:238492	30/101 (30%)
		PDZ_signaling	370..450	CDD:238492	19/89 (21%)
		HN_L-whirlin_R2_like	513..597	CDD:259823	24/113 (21%)
		PDZ_signaling	905..976	CDD:238492	12/60 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910