DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and apba2a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_021326395.1	Gene:	apba2a / 100330365	ZFINID:	ZDB-GENE-121107-1	Length:	923	Species:	Danio rerio

Alignment Length:	739	Identity:	141/739 - (19%)
Similarity:	256/739 - (34%)	Gaps:	222/739 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 TGLQLVSAPKVHIAGEYLASEQQQQQQQQQQQHQQVQEQQQLGR--RKAAAAAEI---------N 148
            |....|.||        :|.:::.:::.::...::..|::..|.  ......||:         |
Zfish   191 TETTFVQAP--------MAEDEEDEEETEEDVEEEDSEEEDNGGFFHYEGNEAELNNNEIPHKDN 247

  Fly   149 LANQVYWLGK------------QKTRSRSRSNSVGNRSI---TSC-----MGGGGGGGEKERERG 193
            .:|.....||            |::| ||:.|...:|.:   ::|     |       |:.|::.
Zfish   248 CSNVCRREGKSPPQEFSRVKVGQESR-RSQDNPKYSRDVPLGSNCTQRDRM-------ERVRDKN 304

  Fly   194 GDRDRPYIRNVDDLLQALGKRDGGDN---------NSNLLETASTHSSSQRRRFKKG---DRTTW 246
            |. |.|.:.|.....::  ::|...|         ..|..|||....|:...:.|..   ||.||
Zfish   305 GS-DCPKVSNAPVARES--RKDSRQNFKYRGHHLETKNNRETAYQGHSAVTIKGKSADAEDRGTW 366

  Fly   247 -EYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRL------QVNDRIIS 304
             :.|.:..:|....|      |..:|.|..:..|     :..|..|.:..:      ..|:|.||
Zfish   367 KKRHLLKYSREDARG------GDGNNSHKRSKSP-----ENCKNRPQDHPICSHKSNGENERKIS 420

  Fly   305 VN-GVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGG 368
            .| ...:||......:....:||.|      :..|....|..||.:...:.|.|| |...:...|
Zfish   421 GNVEARIENEVKTKLIIAPNNSGRT------KVAPDQAKNVKGAPESPRASSASS-GKRNSKPRG 478

  Fly   369 VAPTPITS----------------LSQPN--SLNSSLVQNASSGQPIKVTLTKGGKKDDY----- 410
            .|.||:.|                .::||  .::.|..|::|:|.|......:..:...:
Zfish   479 QANTPVQSPAKQVNKDSAKPVEEEKTRPNEEQVSQSASQDSSTGPPSGQNRPQTQRNPSFPSFVD 543

  Fly   411 ------------GVV-----LGCRLFV------KEISSKAREQ-------LNANGYSLQEGDII- 444
                        |::     ||....:      |.:..|..::       :.....||.|.|:.
Zfish   544 IPGPCEPEDLINGIIFAANYLGSTQLLSDRNPSKSVRMKQAQEAVDCVKAVEVETQSLTEIDLFI 608

  Fly   445 ----TRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVL---RDITNQTA-VSQLNLNNSASHQASG 501
                .::.|.:..:|| :..|.:.|....:..|:|||   |.::|.:. .::..||:.|:|:...
Zfish   609 STKAIKVLNADTQETM-MDNALRTISYIADIGNVVVLMARRRLSNSSLDCTESGLNSDANHKQYR 672

  Fly   502 NIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPR 566
            .|....:.            ||..|...:...:.::..|...|        .||:|       |:
Zfish   673 MICYVFES------------EDAQLIAQSIGQAFSMAYQEFLR--------ANGIN-------PK 710

  Fly   567 GRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQED---FYSSR--RQLYE 626
            ..|:....|.::.|::                              ..:|   |.:|.  :||:.
Zfish   711 DLSQKDYSDILNTQEM------------------------------YNDDLVHFSNSDNCKQLHL 745

  Fly   627 ERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVT 690
            |:|..|...:...:.|...|..|      :.:..:....||:..| |..||:|:.|||..:.|:.
Zfish   746 EKQKGEILGVVIVESGWGSILPT------VILACMLNNGPAARSGKLNVGDQIMAVNDTSLVGLP 804

  Fly   691 RE--EAVLFLLSLQDRIDLIVQYC 712
            ..  :.::..|....::.|.|..|
Zfish   805 LAACQGIIKALKNHVQVKLSVVSC 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	19/91 (21%)
		PDZ_signaling	396..477	CDD:238492	17/120 (14%)
		PDZ_signaling	633..710	CDD:238492	16/79 (20%)
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
apba2a	XP_021326395.1	CBF	<21..114	CDD:332044
		PTB_X11	550..709	CDD:269919	33/186 (18%)
		PDZ	742..823	CDD:278991	20/86 (23%)
		PDZ_signaling	831..904	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910