DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and tjp3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_004911110.1	Gene:	tjp3 / 100127773	XenbaseID:	XB-GENE-995512	Length:	1038	Species:	Xenopus tropicalis

Alignment Length:	1075	Identity:	299/1075 - (27%)
Similarity:	482/1075 - (44%)	Gaps:	238/1075 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 RFKKGD---RTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQV 298
            ||:..|   .|.||.:||.:.|.|..|||||:|||||.|...:||.|:.||||::||||:.|||.
Frog     4 RFQVSDMEEMTIWEQYTVTLIRDPRRGFGIAISGGRDRPLGTDGDNSVIVSDVIRGGPADGRLQT 68

  Fly   299 NDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKR----RVPLN------------------- 340
            .|||:.|||||:|||..:.|:|.|:....|..:.|||    ::|::
Frog    69 RDRIVMVNGVSMENVSSSFAIQTLKSCAKTANVTVKRPRKIQIPVSNSMHPASTYSSHTQKSSDP 133

  Fly   341 -------------------------------PINAAGAVQHQHSHSLSSVGLMAN---------- 364
                                           |.:.|...:...|...||.|..::
Frog   134 VFSDTSRREKDDGSDSPLPWRGRYESSNQEPPEDTARGYEGDSSSGRSSQGSFSHSSRHTRHRRG 198

  Fly   365 ---GSGGV---------------------------APTPITSLSQPNSLNSSLVQNAS------- 392
               ||.||                           ....|.|.|:.....|...:..|
Frog   199 RTVGSEGVDYAKRKVGRETVSSGSETGRRSRRRESGSDVIDSSSEARGYYSKRKETGSEMGGSGS 263

  Fly   393 -------------SG-----------QPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNA 433
                         ||           :|||..|.|..:..:||:.||.::|:|.|:...   |.|
Frog   264 EIGERYQNGLELVSGFKRLPIQDVPAKPIKAVLVKRAENQEYGLKLGSQIFIKHITESG---LAA 325

  Fly   434 NGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQ 498
            ...:|||||:|.:|:... .:.|||.:.:::|:..:.:|.|.||||                :.|
Frog   326 QEKALQEGDLILKINGVT-SENMSLADTRRLIEKSRGKLTLTVLRD----------------NRQ 373

  Fly   499 ASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPP-------TRTSNGPNINGNGL 556
            ...||......:..|.||...::.:   .|...:...:....||       |..|:|......|:
Frog   374 FLVNIPEVRDSESEGRSSPREDISE---IGSEDFPPPSEAPPPPPAHQQISTSESDGSASEEQGM 435

  Fly   557 NDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAI-----DEPPRPPPPRGSSGGAAQED 616
            |..               :.|...:..:.....:...|.:     :|...|       ....:||
Frog   436 NGS---------------EAVQKMENSKVEIAVKNEEAQVVSTYREESVNP-------NNNTRED 478

  Fly   617 FYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKV 681
            ..:.        .|.:.|.|.|.||.|:|:||.|||:.||||.|||..|||..:|:..||:||:|
Frog   479 LRTG--------YSPDARVIQFMKEKSIGLRLAGGNDVGIFVAAVQAASPAEREGMKEGDQILQV 535

  Fly   682 NDMDMNGVTREEAVLFLLSLQDRIDLI--VQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEM 744
            ||...:.:|||:||.:|:.|....|:|  .|..::.|.:::.:..||||:|:|||..::.:...:
Frog   536 NDTSFHNLTREDAVQYLMGLPQNEDVIFLTQGKEDIYRKMIKSNVGDSFYIRTHFDYESDAPSGL 600

  Fly   745 AFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANES 809
            :|..|::|.::||::.|.:|||..:::.|..:|.::|:|||.:|||:.|:.:  ...|..:::..
Frog   601 SFTRGEIFHIVDTMYRGKIGSWLAVRVARDLKEKEKGIIPNNNRAEQYASLE--PVLKPQSSSGQ 663

  Fly   810 RGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARER 874
            |..|::.|..  |.:|.|.|::.:|:.......|:|.|||||||...|.||||:.||::|:|.::
Frog   664 RAEFWKLRGL--RGAKKLLRKSREDLAALSKKIKYPPYERVVLREASFKRPVVVMGPITDIAHQK 726

  Fly   875 LAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVV 939
            |..|.|.:|.:.   :..:....|..::::|..:|::..:.|||||:|||.||:.|||.||||:|
Frog   727 LCADLPQEFESA---ESVTRDGGGTSKVIKLDVVREIAAKNKHALLEITPTAVEHLNYMQFYPIV 788

  Fly   940 IFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSD-EESWYRKLRDSI 1003
            :|...:::..:|.:|..|...:.|||::|..|..|..:...|:|:..|.||. .:||.|.|::.|
Frog   789 VFCNPENRQGVKAMRKWLLPDSRKSSRRLYAQAVKQRKNNFHLFTATINLSGASDSWLRSLKEII 853

  Fly  1004 DLQQSGAVWMSESK------PVESLSDDFLFPMTTSR----LSYASSPESDLELSPGPSASLSLG 1058
            ..:|:..:|.:|.|      |::.|.|      :|:.    ||..|...||.|.:.....:.:..
Frog   854 QTEQTKPIWTTEDKENTITEPLDLLDD------STAEVNDYLSCDSRANSDYEETDAEGGAYTDQ 912

  Fly  1059 NLPQLVKASSDPSIA-TNQDNLDRDRDIIGEGLPPPYTVPY-DHAVPANPNRRQTMD----SSKY 1117
            .|.:.::   :|::| :::..||..........|..|...| |.::|...|...|..    ||.|
Frog   913 ELEEEIQ---EPALARSSEPVLDYQSTYYRAHSPDDYPSEYKDQSLPETNNIHGTKPRPELSSNY 974

  Fly  1118 --SIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINA 1150
              |:...:..|||:        :..:||..:..:|
Frog   975 RSSLPSNDDSPQQE--------SVSQPQGQWSASA 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	44/84 (52%)
		PDZ_signaling	396..477	CDD:238492	27/80 (34%)
		PDZ_signaling	633..710	CDD:238492	39/78 (50%)
		SH3_ZO	729..790	CDD:212793	20/60 (33%)
		GuKc	831..1007	CDD:214504	64/176 (36%)
		ZU5	2263..2351	CDD:279170
tjp3	XP_004911110.1	PDZ_signaling	19..104	CDD:238492	44/84 (52%)
		PDZ_signaling	292..368	CDD:238492	26/79 (33%)
		PDZ_signaling	489..552	CDD:238492	34/62 (55%)
		SH3_ZO-3	582..646	CDD:212961	23/63 (37%)
		NK	681..857	CDD:388413	65/178 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7423
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm47496
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010