DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and apba1a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_001343372.1	Gene:	apba1a / 100003938	ZFINID:	ZDB-GENE-060526-175	Length:	968	Species:	Danio rerio

Alignment Length:	766	Identity:	143/766 - (18%)
Similarity:	232/766 - (30%)	Gaps:	265/766 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1491 HMQPPPPQQQQPTYGGS---NGNYGQAPPPQSYPQANGYNGNG-----HHYNGGSGTGPYIAPHR 1547
            |.:.|..|:.:......   .|..||.||.....:.|  ||:|     ...|.|:....:.:.|:
Zfish     3 HQEAPHGQELREAAEADLERRGPEGQQPPSSHRRRHN--NGDGSSRSNRSRNHGTENNHHQSQHQ 65

  Fly  1548 GMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMSEMEPYDERYDDYYN 1612
            |.|                              .||:.: |:..|.:...:...|.:|...:...
Zfish    66 GAP------------------------------RYRRCE-GSNGGTNRTHAARRPEEEGDAEQQT 99

  Fly  1613 MPPPAAHPS------QGHHMQRSRSAPRYPHERPPHAQDPNYYGHYGTSRGHSQPRQQYSQHHQQ 1671
            :..|...|:      ||.:..|.|:..:...:|....:|             ::..:|:....||
Zfish   100 IQQPIPRPAVTRYRRQGDNEARLRAQQQRQRQRERQQRD-------------AERAEQHRLEQQQ 151

  Fly  1672 QYYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLKSTRPLRRMNSMVEPERKPKGLRRQQSM 1736
            |                       |.||        .::..|.|      |||...:......|.
Zfish   152 Q-----------------------LLSP--------TQTMLPTR------EPEEAEEDEGDGSSA 179

  Fly  1737 LERGVQRPYYPDEYPTYPAGFE---ERAHGGQGMM---QPHSQDAYYQRGGHYAPQQQEMMNSTY 1795
            |.|..          :..:||.   :||.|...|:   :|..::.|   |....|:.:|...|.
Zfish   180 LARSA----------STESGFHNHTDRAEGDAVMVLEAEPEDENTY---GIPLRPEAEEYTESA- 230

  Fly  1796 QNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLERRQAEAAAASGGRNGRRIVRR 1860
               |.|..:|......|:.|
Zfish   231 ---ESEQQHGGPAYLQPQYP--------------------------------------------- 247

  Fly  1861 HSTTTADRGGNPGPP----------RRPM----ISPGYE---------QDPQEIYQTRNGAYMLP 1902
                       |.||          .||:    ::|.|.         .:|.|..:...|.....
Zfish   248 -----------PQPPPLPREPLPNAERPLEAETLNPNYSSYVYTQPMYHNPTEAGEAHEGGATED 301

  Fly  1903 DQRRAPSSEVMTRRRFYPGAANEQTEEEPLYQSRREMQREMQR--------NHLYQSKREMQERI 1959
            :|...|..:...:...|     |:..:.||  ||.|.|...|:        ..|||.:..:..|:
Zfish   302 EQYSEPYVDYTLQEHVY-----EEITDAPL--SRAEGQTPQQQRPEFRLFERDLYQQQEAVGSRL 359

  Fly  1960 ------SQGKRD---MEREFSPQSSSSQSEASNSEAIYQSRREAKESALKTRSQLRDQIYQTRRE 2015
                  |.|:.|   .|.||:|...:...|  ..|.|.|...|.||| |.::|
Zfish   360 HHYDERSDGESDSPEKEAEFAPYPRADSCE--QDEDIDQIVAEVKES-LSSQS------------ 409

  Fly  2016 ALDSMAEPIYVSKRGMGRPAPIYETREESILQSRENETD-----EKKEKECKTEQIQVEINAQPE 2075
             ||.:|       .|:.:.....|...||....:.|:.:     .:.|......:.|..:.....
Zfish   410 -LDRIA-------MGLNKDGDKEEDWPESESHGQLNDNNPLEPVSEGELPRSPSEDQAPVIRSSR 466

  Fly  2076 EQIEDSTLSRSDLQKSSDTVIENPARAPLVQDE-------VDDDEEEEVQDQRDP---AESSADQ 2130
            |:.:..:|:..|::::.:.|.....|:|...||       :..|.....:....|   |:|....
Zfish   467 EKRDAISLAIKDIKEAIEEVKTRTVRSPYTPDEPKEPIWVMRQDLSPTAESDLQPSLGADSPGSG 531

  Fly  2131 TEQPTAIENNLHNEGMVEQSQNDSDDVFEAADKVS--PLAPPPAPVQPPTP 2179
            :..|...|::.|.  |:.|..:||.:....|.|.|  .||..|..|:.|.|
Zfish   532 STSPQGAESSSHQ--MMSQEGSDSFESPSPAGKESRRSLASFPTYVEVPGP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
apba1a	XP_001343372.1	PTB_X11	583..754	CDD:269919
		PDZ	787..870	CDD:278991
		PDZ_signaling	876..949	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910