DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hng2 and madf-2

DIOPT Version :9

Sequence 1:	NP_649837.1	Gene:	hng2 / 41056	FlyBaseID:	FBgn0037634	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_492896.1	Gene:	madf-2 / 173019	WormBaseID:	WBGene00009461	Length:	290	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	43/245 - (17%)
Similarity:	87/245 - (35%)	Gaps:	79/245 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IDAVHKRSIIWERSHPNFHN-RELRDEAWQQIGHELCSNFDDSSEPEKQEIVK----TLLKRWKN 81
            |:|:..|.:||::::....| |.|:....:::..||.|.|        |..:|    .:..:|||
Worm    13 INAIRNRPVIWDKNYFGESNYRTLKTSCLREVTSELNSMF--------QMPIKFTCEDVRSQWKN 69

  Fly    82 TRDSYLRVNRLRQSGEEVARA----SYIYEKELSFLLNVKAESEDDV------------------ 124
            .:|:::|..|....|:.:..|    ::.:.:.|:||...:|:...|.
Worm    70 LKDTFVRKLRWVHEGKYMEDAMKEPTWKFYRMLTFLDEKEAKRLGDTCEHTYELAPNSTSCGQRA 134

  Fly   125 --------------ESLKEQPKPQAKRKRV------------------------STAAQRS---- 147
                          :....||.||..::.:                        ||:.:|.
Worm   135 QISYEPTSTEEKMFQMFNNQPPPQLSQQSMIDSSQIATCSNEPKMTSSSTFVTSSTSLKRGVHYS 199

  Fly   148 -AKTPRKRNSDQESNIEPAIRNPAIPSNINTVLGDLGCAKEDTATPEIAY 196
             .::|...:|..|..:|.....|....:....:.::...:..| ||.:|:
Worm   200 PTRSPNGSSSGLEEELEDEDEQPGRKKSCRRQVSNIQPMQVIT-TPPVAH 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hng2	NP_649837.1	MADF_DNA_bdg	21..113	CDD:287510	23/99 (23%)
hng2	NP_649837.1	BESS	216..250	CDD:281011
madf-2	NP_492896.1	MADF	11..107	CDD:214738	25/101 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930