DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9839 and ERCC6

DIOPT Version :9

Sequence 1:	NP_001262388.1	Gene:	CG9839 / 41055	FlyBaseID:	FBgn0037633	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_000115.1	Gene:	ERCC6 / 2074	HGNCID:	3438	Length:	1493	Species:	Homo sapiens

Alignment Length:	730	Identity:	132/730 - (18%)
Similarity:	231/730 - (31%)	Gaps:	315/730 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRKQQLKPRQDDHRSPVKRRSVDIKSEPLDGYP-ALADYDLSTADIKPDLTELQLQLVAE---QQ 67
            |::::||    .|...:::|::..:.:.  |.| |...::   :|::|:         ||   :.
Human   323 KKEERLK----KHIKKLQKRALQFQGKV--GLPKARRPWE---SDMRPE---------AEGDSEG 369

  Fly    68 AASNTIRLELEQQESDSDEDGYSELDYQAEDVFCQDDMDDYD----PDWSSQQTGSRLLFKFPIQ 128
            ..|.....|.|::|.|.:.:| :|.|...       |..||:    |....:|.      |.|:|
Human   370 EESEYFPTEEEEEEEDDEVEG-AEADLSG-------DGTDYELKPLPKGGKRQK------KVPVQ 420

  Fly   129 Q-----------------------SGLKFGQ-RFQGPQHYFNQVLGNRSKFFSSLAQSCNLKGGE 169
            :                       .|.|.|: |..|.:.|:.|.|...:|.        .|:..|
Human   421 EIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKL--------RLQDKE 477

  Fly   170 LKSNPTTAEEMEIFMALSLLMCDLKLEHLSDYWSTNMFYGLVGFSGKIP------LERYQQL--- 225
            .:                     ||||..|:........|.     |:|      |.:|||.
Human   478 KR---------------------LKLEDDSEESDAEFDEGF-----KVPGFLFKKLFKYQQTGVR 516

  Fly   226 ----LHCLNFDAPQLQAGRAKVKNSLLLDFINERMEEIYICGQQLVLNEPITL--WKGALRYQDE 284
                |||       .|||.                    |.|.::.|.:.|.:  :...|.|
Human   517 WLWELHC-------QQAGG--------------------ILGDEMGLGKTIQIIAFLAGLSY--- 551

  Fly   285 LPNKFRTNALLLHMLTEQSGLVVKILPEIVRKEDAPAWVRN-------SRQLVEHRNKIVLKLME 342
              :|.||..  .:...|..|..|.:.|..|..:    ||:.       .|..:.|..
Human   552 --SKIRTRG--SNYRFEGLGPTVIVCPTTVMHQ----WVKEFHTWWPPFRVAILHET-------- 600

  Fly   343 GYHGGRTVYTSKFYGSYGLAQE-LAKKSTYCTGLL------------DRNRYGNSKALV---HQR 391
                          |||...:| |.:...:|.|:|            |.:||.....::   |:.
Human   601 --------------GSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDEGHKI 651

  Fly   392 LDSNSISTSYATSLMMAKWR----------------RRAKSLYCF----SSDCLAIYSKEMAMQK 436
            .:.|:     |.:|...::|                |...||:.|    ....|.::.::.::..
Human   652 RNPNA-----AVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPI 711

  Fly   437 T-----NAKPKLIQELEFQLRPGNDGRHHLIHYQAAC-----------KELKANIKLTIFLLNIL 485
            |     ||.|..::..                |:.||           :.:|:::|:::.|.:
Human   712 TMGGYSNASPVQVKTA----------------YKCACVLRDTINPYLLRRMKSDVKMSLSLPD-- 758

  Fly   486 VYNAYLLY--FANGQNARVGHLKSYSEF-------RVI-----IIKSLLR-EEVTNEPVTSIQKP 535
             .|..:|:  ..:.|:      |.|..|       |::     |...|:. .::.|.|......|
Human   759 -KNEQVLFCRLTDEQH------KVYQNFVDSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGP 816

  Fly   536 ETYERSKN-KPVPEPRLKTILHEPMLIQQNGKPAKKNCRYCHKGGMLQFSRYMCNTCPDKPGLCQ 599
                  || |.:|:..|:.        .|.|        |..:.|.:               :..
Human   817 ------KNLKGLPDDELEE--------DQFG--------YWKRSGKM---------------IVV 844

  Fly   600 EPCFLLWHEQLKKVI 614
            |....:||:|.::|:
Human   845 ESLLKIWHKQGQRVL 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9839	NP_001262388.1	DDE_Tnp_1_7	141..490	CDD:290555	74/422 (18%)
CG9839	NP_001262388.1	Tnp_zf-ribbon_2	570..602	CDD:290554	3/31 (10%)
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269\|PubMed:29203878	1..510		48/252 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..323		132/730 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..453		26/136 (19%)
		SNF2_N	510..812	CDD:278600	69/391 (18%)
		DEXDc	527..677	CDD:238005	35/207 (17%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	646..649		0/2 (0%)
		HELICc	830..960	CDD:238034	9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1318..1384
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269\|PubMed:20541997	1400..1428
		Winged-helix domain (WHD). /evidence=ECO:0000305\|PubMed:29203878	1429..1493
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269\|PubMed:26620705	1446..1493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960