DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT7 and CCT3

DIOPT Version :9

Sequence 1:	NP_649835.1	Gene:	CCT7 / 41054	FlyBaseID:	FBgn0037632	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	544	Identity:	162/544 - (29%)
Similarity:	294/544 - (54%)	Gaps:	28/544 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQPQIVLLKEGTDSSQGKPQLVSNINACQSIVDAVRTTLGPRGMDKLIVDAHGKATISNDGATIM 65
            ||..:|.:....:.:.|:...:|||.|.:::.|.:||.|||:.|.|:::|..|...::|||..|:
Yeast     1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAIL 65

  Fly    66 KLLEIIHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPF-VEEGVHPRVIIKAIRKALQ 129
            :.:::.|||||::::::::||.|||||||:|::||||.|.|..|: :|:.:||.:||:|::|||.
Yeast    66 REIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALT 130

  Fly   130 LCMEKINEMAVQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVLSLDELLPLNMI 194
            ..:|.|.::: :.|:...|   |.::|....::.:|.:....:....:.:|||.::.:.|...:.
Yeast   131 DALEVIKQVS-KPVDVEND---AAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVE 191

  Fly   195 G-------------IKKVTGGSLEESQLVSGVAFKKTFSYAGFEMAPK---SYDNCKIALLNIEL 243
            |             ::|:.||.:.:|:::.||...|...:      ||   ..:|.::.||:..|
Yeast   192 GEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVH------PKMSRHIENPRVVLLDCPL 250

  Fly   244 ELKAERDNAEIRVDNVKEYQKVVDAEWQILYNKLAKIHESGANVVLSKLPIGDVATQYFADRDIF 308
            |.|.......|.::..:::.:::..|.:.:.....:|......:|:::..:.|:|..|.......
Yeast   251 EYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCS 315

  Fly   309 CAGRVPEEDLKRTMKACGGAVMTTANDIKPNVLGL-CEHFEERQVGGERFNLFQGCPNAKTSTLI 372
            ...||.:.|..|..:..|..::....|:|.:.:|. |..|:...:|.|.|:....|...|..|::
Yeast   316 VLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIM 380

  Fly   373 LRGGAEQFLEETERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRTIAGKEQLLIAAI 437
            ||||::..|.|.:|:|.||:.:.|..:...|:..||||.||.:|..|.:.::.:.|.:|....|:
Yeast   381 LRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAV 445

  Fly   438 AKGLEIIPRQLCDNAGFDATNILNKLRQKHAQGGQWYGVDINKEDISDNYEQCVWEPSIIKINAL 502
            |..:|.|||.|..|||.|...:|::||.|||||....|:|.:|..|.|.....:|||.:||..::
Yeast   446 ADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSV 510

  Fly   503 TAAAEAACMILSVDETIKSPKAGE 526
            ..|.|:||::|.||:.:...:..|
Yeast   511 KTAIESACLLLRVDDIVSGVRKQE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	chap_CCT_eta	2..524	CDD:274086	160/539 (30%)
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	159/537 (30%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	159/538 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810