DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT7 and CCT6

DIOPT Version :9

Sequence 1:	NP_649835.1	Gene:	CCT7 / 41054	FlyBaseID:	FBgn0037632	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_010474.3	Gene:	CCT6 / 851768	SGDID:	S000002596	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	540	Identity:	140/540 - (25%)
Similarity:	258/540 - (47%)	Gaps:	27/540 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLKEGTDSSQGKPQLVSNINACQSIVDAVRTTLGPRGMDKLIVDAHGKATISNDGATIMKLLEII 71
            ||....:|.:....|..|:.:.:.:...:.|.|||:|..|::||..|...::.||..::..::|.
Yeast     5 LLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQ 69

  Fly    72 HPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPFVEEGVHPRVIIKAIRKALQLCMEKIN 136
            .|.|..:...|.:||...|||||:||.|.||.|:|...|::||||||:|......|.:..|:.::
Yeast    70 SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLD 134

  Fly   137 EMAVQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVLSLDEL----LPLNMIGIK 197
            |..:.....|.|  |..|.:.|.:::.:|:.....:..:.||.|||||:.:.    |.|:|:.|.
Yeast   135 EFKISKTNLSND--REFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197

  Fly   198 KVTGGSLEESQLVSGVAFKKTFSYAGFEMAPKSYDNCKIALLNIELELKAERDNAEIRVDNVKEY 262
            ::...|.:::..:.|:.......:...   |....|..:.:||:.||.:....|:.....:..:.
Yeast   198 QMQHLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQR 259

  Fly   263 QKVVDAEWQILYNKLAKIHE-----SGAN-----VVLSKLPIGDVATQYFADRDIFCAGRVPEED 317
            .|:..:|.:.:..||.||.:     .|.:     |::::..|..::...||..:|....|....:
Yeast   260 DKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRN 324

  Fly   318 LKRTMKACGGAVMTTANDIKPNVLGLCEHFEERQVGGERFNLFQGCPNAKTSTLILRGGAEQFLE 382
            ::|.....||....:..|:.|.:||......:..:|.|:|.......:.|:.|::::|.....|.
Yeast   325 MERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALA 389

  Fly   383 ETERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRT---IAGKEQLLIAAIAKGLEII 444
            :|:.::.|.:..|...:|..:::.|.||..:.||:.||..:..   ..||.:..|.|.|:.|.:|
Yeast   390 QTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVI 454

  Fly   445 PRQLCDNAGFDATNILNKLRQK--HAQGG---QWYGVDINKEDISDNYEQCVWEPSIIKINALTA 504
            |:.|..|:|||..::|..:..:  .||..   ::.|||:|..|..|...:.:|:...:..||:|.
Yeast   455 PKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITG 519

  Fly   505 AAEAACMILSVDETIKSPKA 524
            |...|..:|..||.:::.::
Yeast   520 ATGIASNLLLCDELLRAGRS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	chap_CCT_eta	2..524	CDD:274086	140/538 (26%)
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	140/538 (26%)
CCT6	NP_010474.3	chap_CCT_zeta	2..542	CDD:274088	140/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810