Protein Alignment CCT7 and CCT3

DIOPT Version :10

• Sequence 1: NP_649835.1
• Gene: CCT7 / 41054
• FlyBaseID: FBgn0037632
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_005989.3
• Gene: CCT3 / 7203
• HGNCID: 1616
• Length: 545
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 125/639 - (19%)
• Similarity: 213/639 - (33%)
• Gaps: 201/639 - (31%)

  Fly   230 KKHAEGVWLQNI----GNRTRKHQDSISGLSGTFSGWFNPMKPTTPSINQSEIFS-SRAAINTLG 289
            ||..|.:.||.:    ..:..|.|..::.....|......|:    .:.|..:.| .|..:.|:
Human   177 KKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQ----QLQQQHLLSLQRQGLLTI- 236

  Fly   290 IRNPGSKT-PVGSLKFLNGLLPDLILSSPPVITAAETPVVYPSQQITSTSESPVLSTTDNSPYLG 353
              .||... |:..|  ..|::|..:......:|:|.|     :::.||::.|.:..|   |..:.
Human   237 --QPGQPALPLQPL--AQGMIPTELQQLWKEVTSAHT-----AEETTSSNHSSLDLT---STCVS 289

  Fly   354 SEAKQRSTSLPEYVNVSHVIRPTPPLPEEPSRTNHHEVIHRKASTMTTPARESPRFSNCGEHKDF 418
            |.|..:|         |.::.|       .:.||....:|       ||.|||....   ||
Human   290 SSAPSKS---------SLIMNP-------HASTNGQLSVH-------TPKRESLSHE---EH--- 325

  Fly   419 MPNRIPSKGRSMM----------DF-STLPYEDSGSRYESWRRA-------------------KK 453
             |:..|..|..:.          || :.|.:.:|....:....|                   |:
Human   326 -PHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKE 389

  Fly   454 FISAFSQKSHQDLYKSAPKIGKRKASSTSALTYRTHESKHSFALSTSSSSEVDELPPPALNVAVT 518
            .:.|  ..:|..:..:.||...:..:..|::|           ||.|:|    |..|.:|....|
Human   390 RLQA--MMTHLHVKSTEPKAAPQPLNLVSSVT-----------LSKSAS----EASPQSLPHTPT 437

  Fly   519 NPAPPLIPRKDKSNEPEIIPAGLVRLREEGSLKMR--GGVNIALARRLAAGINGSFTKYDGDRGT 581
            .|..||.|   .:..|.:|..  ..:...|.::.|  ...|:.::..:|.  |..|.|....|..
Human   438 TPTAPLTP---VTQGPSVITT--TSMHTVGPIRRRYSDKYNVPISSDIAQ--NQEFYKNAEVRPP 495

  Fly   582 HVYP--------QTPEEKERKIEE--------FIEERRRTASTRKVESPDFS--------NDVLG 622
            ..|.        ::| ||:..:.|        |...||..|:.:.....:.|        .:|.|
Human   496 FTYASLIRQAILESP-EKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKG 559

  Fly   623 KVVSNETEKFRLMERRASSVSFNKANAVQISLLNENQKKAAALITNHNRENSQSESMASSSESLS 687
            .|.:.:..:|:  :||...:|.|.:       |.:|.:.:.|..|..|.  :...|||.:|..|.
Human   560 AVWTVDEVEFQ--KRRPQKISGNPS-------LIKNMQSSHAYCTPLNA--ALQASMAENSIPLY 613

  Fly   688 SDARSKISIKKRSNSPPRTVAPCILPKQPSQRTLTLQQQSSSSIDSLNSTQTTRTTSSVRLPTRI 752
            :.|                          |....||...:|:..:.||..
Human   614 TTA--------------------------SMGNPTLGSLASAIREELNGA--------------- 637

  Fly   753 LVNQSSTSSEGSSGKSQ-------HYFESKVGPK--------TSSTSHPSDSSH 791
            :.:.:|..|:.|.|:|.       |..|..:.|:        .::.:|..|..|
Human   638 MEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDPEEAEGPLSLVTTANHSPDFDH 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	66/329 (20%)
CCT3	NP_005989.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		chap_CCT_gamma	6..529	CDD:274085	85/423 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..545		4/18 (22%)