DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT7 and mkks

DIOPT Version :9

Sequence 1:	NP_649835.1	Gene:	CCT7 / 41054	FlyBaseID:	FBgn0037632	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_021336215.1	Gene:	mkks / 393134	ZFINID:	ZDB-GENE-040426-757	Length:	566	Species:	Danio rerio

Alignment Length:	599	Identity:	123/599 - (20%)
Similarity:	214/599 - (35%)	Gaps:	133/599 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SQGKPQL-----VSNINACQSIV---DAVRTTLGPRGMDKLIVDAHGKATISNDGAT-IMKLLEI 70
            |:.||.|     :||...||.|.   :.:.|..||.|..|.|.:..|...::...:| ::|.||:
Zfish     5 SKKKPALCTDEPLSNSTICQKITLLRNILSTAYGPTGRLKQIHNNVGGHVLTTSTSTALLKRLEM 69

  Fly    71 IHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPFVEEGVHPRVIIKAIRKALQLCMEKI 135
            ..|..|.:....:.......|....:.:.....::..|.:   |:.....||..:..::.|...:
Zfish    70 SEPLLKLISTALQHHTTRYSDSGLFMGIFTLTLIENTKKY---GLRTSTAIKVYKHLVEQCNVYL 131

  Fly   136 N----EMAVQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVLSLDELLPLNMIGI 196
            .    ...|.:...|.|...||......:..:..|..::....|.::..|.|   ..:|.|..|.
Zfish   132 KGDSCGCKVPVEFSSCDSLVALAHSMITSKPACMLDSRETQQISSLITQAFL---YSIPCNSSGT 193

  Fly   197 ----KKVT----GGSLEESQLVSGVAFKKTFSYAGFEMAPKSYDNCKIALLNIELELKAERDNAE 253
                :.||    |.|:..|.:..|:...........::........|:.|..:.|    ..|.:|
Zfish   194 ACFGRTVTIGIEGQSVNHSSVFPGLLLDVPEMLLPGDLERLGDGPFKVVLFGVSL----SGDISE 254

  Fly   254 IRVDNVKEYQKVVDAEWQILYNKLAKIHESGANVVLSKLP-------IGDVATQYFADRDIFCAG 311
            :. |...|..:.::.|..:| .:|.||   |..||..|:.       :..|...|..:.::....
Zfish   255 VG-DVALEVHRGLNPERDLL-QQLLKI---GEQVVKDKVSLFACQKVVHPVLQHYLREHEVVVIE 314

  Fly   312 RVPEEDLKRTMKACGGAVMTTANDIKPN-----VLGLCEHFEERQVGGERFNLFQGCPNAKTSTL 371
            |:....::...|..|...:.:...:.|.     |.|||  |::  .|.::........:|..||:
Zfish   315 RLGLALMEPFAKITGARAVASLFSLVPMEAYGLVAGLC--FQD--CGSKKLLQLLSSKHAAISTM 375

  Fly   372 ILRGGAEQFLEE-------TERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRTIA-- 427
            :|....|..|||       .:|:.|    ::|.|::....:.|||..|.:|:..:...:::.|
Zfish   376 VLCHRNETMLEELKVCAMTCQRAEH----VLRLTLREPYALLGGGCTETQLATHITHMNQSTAPT 436

  Fly   428 -------GKEQLLIA---------AIAKGLEIIPRQLCDNAGFDATNILNKLRQKHAQGGQWYGV 476
                   ...:.|:|         |:|..||           .|..:.|..|...|    :|. :
Zfish   437 TAAALGISHSEFLMAVESFRSSLLAVALSLE-----------HDGQDCLIDLTYGH----RWV-M 485

  Fly   477 DINK-------------EDISDNYEQ------CV-----------WEPSII-----KINALTAAA 506
            ||:.             ||.| |.|:      |.           .:|.::     |:|||..|.
Zfish   486 DISSQTEVKHTCGCGLLEDRS-NLEKTHLNTACQTFSPVFLENNDTQPKVLDSFSAKLNALNVAV 549

  Fly   507 EAACMILSVDETIK 520
            |.|.::|.|...||
Zfish   550 EMASLVLDVKYIIK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	chap_CCT_eta	2..524	CDD:274086	123/599 (21%)
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	123/599 (21%)
mkks	XP_021336215.1	Cpn60_TCP1	29..565	CDD:306598	114/575 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810