DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT7 and Mkks

DIOPT Version :9

Sequence 1:	NP_649835.1	Gene:	CCT7 / 41054	FlyBaseID:	FBgn0037632	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001008354.1	Gene:	Mkks / 311456	RGDID:	1308814	Length:	570	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	111/578 - (19%)
Similarity:	211/578 - (36%)	Gaps:	93/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KPQLVSNINACQS---IVDAVRTTL-----------GPRGMDKLIVDAHGKAT-ISNDGATIMKL 67
            ||.|      |::   ..:.||:||           ||.|..|.:.:..|... .::..:.:::.
  Rat     8 KPSL------CKTEPLTSERVRSTLSVLKGIIASCYGPSGRLKQLHNGLGGCVCTTSQSSALLRN 66

  Fly    68 LEIIHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPFVEEGVHPRVIIKAIRKALQLCM 132
            |.:.||..|.|....::......|......:|....::.::..   |:.|...||..:..|.|.:
  Rat    67 LSVTHPILKVLTSSVQNHVCCFSDCGLFTAILCCNLIENIQRI---GLTPTTAIKLNKYLLGLSI 128

  Fly   133 EKINEMA----VQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVL-----SLDEL 188
            ..:...|    :.:..:|......|:.....:..:..|..::.|....:::.|.|     |.:|.
  Rat   129 SYLKSEACSCRIPVDFRSTHTFLNLVHSILTSKPACMLTRKEIDHIGALILKAFLLTIPESAEER 193

  Fly   189 LPLNMIGIKKVTGGSLEESQLVSGVAFKKTFSYAGFEMAPKSYDNCKIALLNIELELKAERDNAE 253
            :.|....|..:.|..:.:|.::.|:..:.:.......:..:.....::||..  ..|..:..||.
  Rat   194 MVLGKSIIVPLKGQQVTDSTVLPGLLIEASEVQLRRLLPTQKSSTLRVALFC--ASLSGDFSNAG 256

  Fly   254 IRVDNVKEYQ-KVVDAEWQILYNKLAKIHESGANVVLSKLPIGDVATQYFADRDIFCAGRVPEED 317
             ....|..|| .:.:|..:.|.|...::.....::||.:..|.....|:.::..|....||....
  Rat   257 -EGTLVVHYQVSLENAVLEQLLNLGRQLVSDHVDLVLCQKVIHPSLKQFLSEHQIIAIDRVGVTL 320

  Fly   318 LKRTMKACGGAVMTTANDIKPNVLGLCEHFEERQVGGERFNLFQGCPNAKT-STLILRGGAEQFL 381
            ::...|..|...:.:...|.....|..:.....:.|.:.|  |...||..| .:|:|....:...
  Rat   321 MEPLSKVTGATPIGSLYPIVSTTYGSVKDVRSARFGSKYF--FHLLPNEATICSLLLCSRNDTAW 383

  Fly   382 EETERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRTIA---------GKEQLLIA-- 435
            ||.:.:...|:.:::.|||...|:.|||.:|..|:..:|......|         .:.:|.||
  Rat   384 EELKLTCQTAMHVLQLTIKEPWVLLGGGCVETHLAAYIRHKVHNEAEAIVRDDGCSQAELHIATE 448

  Fly   436 AIAKGLEIIPRQLCDNAGFDATNILNKLRQKH--------AQGGQW--------YGVDINKEDIS 484
            |....||.....|..:.|    .||..::..|        |..|.|        .|:..::|::|
  Rat   449 AFCSALESAAVSLEHDGG----EILIDMKYGHFWSCPADSASVGNWPDTLSRCGCGLYNSQEELS 509

  Fly   485 DNYEQCVWEP-------------SI---------IKINALTAAAEAACMILSVDETIK 520
            .:..:..:.|             |:         .|::.|..|.|.|.:||.:...|:
  Rat   510 WSVLRSTYHPFAPQTCLPQAASGSVSNLTVDSFTAKLSGLQVAVETANLILDLSYVIE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	chap_CCT_eta	2..524	CDD:274086	111/578 (19%)
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	111/578 (19%)
Mkks	NP_001008354.1	Cpn60_TCP1	29..569	CDD:278544	103/551 (19%)
Mkks	NP_001008354.1	chaperonin_like	32..456	CDD:295468	81/431 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810