DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT7 and Cct4

DIOPT Version :9

Sequence 1:	NP_649835.1	Gene:	CCT7 / 41054	FlyBaseID:	FBgn0037632	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_877966.1	Gene:	Cct4 / 29374	RGDID:	727937	Length:	539	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	180/530 - (33%)
Similarity:	307/530 - (57%)	Gaps:	30/530 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EGTDSSQGKPQLV--SNINACQSIVDAVRTTLGPRGMDKLIVDAHGKATISNDGATIMKLLEIIH 72
            :|....:.||..:  |||:|.:::.||:||:|||:||||:|.|..|..||:||||||:|.::::|
  Rat    21 KGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLH 85

  Fly    73 PAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPFVEEGVHPRVIIKAIRKALQLCMEKINE 137
            |||:.||:::|:||.|.||||||||::||..|......:::|:||.:|.::.:|||:..:|.:.:
  Rat    86 PAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTD 150

  Fly   138 MA--VQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVLSLDE-----LLPLNMIG 195
            |:  ||:      ..|..|...|.|:::||::.|.....|.:.|:||:.:.:     .:.|..|.
  Rat   151 MSRPVQL------SDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIK 209

  Fly   196 IKKVTGGSLEESQLVSGVAFKKTFSYAGFEMAPKSYDNCKIALLNIELEL-KAERDNAEIRVDNV 259
            |.|..||::::.:||.|:...:..:.:|.....|:    ||.|:...|.. |.:.|| :|.|.:.
  Rat   210 IVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKA----KIGLIQFCLSAPKTDMDN-QIVVSDY 269

  Fly   260 KEYQKVVDAEWQILYNKLAKIHESGANVVLSKLPI-----GDVATQYFADRDIFCAGRVPEEDLK 319
            .:..:|:..|...:.|.:.:|.::|.||:|.:..|     .|:|..:.....|.....:..||::
  Rat   270 AQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIE 334

  Fly   320 RTMKACGGAVMTTANDIKPNVLGLCEHFEERQVGGERFNLFQ--GCPN-AKTSTLILRGGAEQFL 381
            ...|..|...:...:...|::||..|..||..:.|.. .||:  ||.: .||.|:::||..:..:
  Rat   335 FICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSG-KLFKITGCTSPGKTVTIVVRGSNKLVI 398

  Fly   382 EETERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRTIAGKEQLLIAAIAKGLEIIPR 446
            ||.|||:|||:.::|..:|..:::|||||.|:||:..|.:||||::|.|...:.|.|..:|:||.
  Rat   399 EEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPS 463

  Fly   447 QLCDNAGFDATNILNKLRQKHAQGGQWYGVDINKEDISDNYEQCVWEPSIIKINALTAAAEAACM 511
            .|.:|||.:..:.:.:||.:||||.:..|:::.|..||:..|:.|.:|.::.::|||.|.|....
  Rat   464 TLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRS 528

  Fly   512 ILSVDETIKS 521
            ||.:|:.:.:
  Rat   529 ILKIDDVVNT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_649835.1	chap_CCT_eta	2..524	CDD:274086	180/530 (34%)
CCT7	NP_649835.1	TCP1_eta	4..524	CDD:239456	180/530 (34%)
Cct4	NP_877966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		1/6 (17%)
		TCP1_delta	25..538	CDD:239454	179/524 (34%)
		Cpn60_TCP1	44..539	CDD:278544	173/507 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820