DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir85a and Grid2

DIOPT Version :9

Sequence 1:NP_649833.1 Gene:Ir85a / 41052 FlyBaseID:FBgn0037630 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_077355.2 Gene:Grid2 / 79220 RGDID:68368 Length:1007 Species:Rattus norvegicus


Alignment Length:460 Identity:81/460 - (17%)
Similarity:162/460 - (35%) Gaps:109/460 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 VPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQGTILGTDGLLAAYVAERLNATMMITRPHS 251
            |..||:.|.....|:..||.:.             ||..:.....|:.|:.  .|..:.:...|.
  Rat   446 VTVLEEPFVMVSENVLGKPKKY-------------QGFSIDVLDALSNYLG--FNYEIYVAPDHK 495

  Fly   252 YNN-------HNLSSDICFLEVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKT 309
            |.:       :.|..::.|     :..|:.::...:.||. ....:.|..:....:.|::.:|:.
  Rat   496 YGSPQEDGTWNGLVGELVF-----KRADIGISALTITPDR-ENVVDFTTRYMDYSVGVLLRRAEK 554

  Fly   310 APTFWNIFRSFGSLVWALILVSVLVANVFCYILKSEVGRVPMQLFAGALT--------------- 359
            ....:.....|...:||.|..:||:..:..|:|.   ...|.:|..|::|               
  Rat   555 TVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN---WLNPPRLQMGSMTSTTLYNSMWFVYGSF 616

  Fly   360 ------MPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARS--- 415
                  :|.|.:    :.|:.:..|..|.|::.|::..||.:.:........|..|..|::.   
  Rat   617 VQQGGEVPYTTL----ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDI 677

  Fly   416 HYHIIIRPRHVKHIQHFLTLGHKHESRI-------REQMLEVSDTQMYEMM-RNNDIRFAYLE-- 470
            .|..::.....:|:            |:       |:.|.    :||:.|: |:|......||  
  Rat   678 PYGTVLDSAVYQHV------------RMKGLNPFERDSMY----SQMWRMINRSNGSENNVLESQ 726

  Fly   471 ------KYHIARFQVNSRV--HMHLGRP--LFHLMNSCLVPFHAVYIVPYGSPYLGFLDSLIRSS 525
                  ||....|..::.|  ::.:..|  .|:.:.:.:........:.:||||.......|...
  Rat   727 AGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILEL 791

  Fly   526 HEFG-----FERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACI 585
            .:.|     ..::|.:........|    |:.::..|     .|.::....||.:...||.::|:
  Rat   792 QQSGDMDILKHKWWPKNGQCDLYSS----VDAKQKGG-----ALDIKSLAGVFCILAAGIVLSCL 847

  Fly   586 VLAWE 590
            :...|
  Rat   848 IAVLE 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir85aNP_649833.1 None
Grid2NP_077355.2 Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424 24..345
Periplasmic_Binding_Protein_type1 28..429 CDD:415822
PBP2_iGluR_delta_2 440..806 CDD:270449 70/403 (17%)
Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453 921..991
PDZ-binding. /evidence=ECO:0000250 1005..1007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349992
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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