DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and grin3a

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	580	Identity:	118/580 - (20%)
Similarity:	189/580 - (32%)	Gaps:	172/580 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 IRKKSAAKHRSHVFLLVRDADTV-SDAWMRASFRQFWKIWLLNIVILY--------------WRD 161
            ::::|.....||.|:.....|.: ...|.|..   .||..  .:|:.|              ||.
Zfish   456 VQEESTIISESHHFIWNLQHDPIGKPMWTRLG---SWKHG--KVVMDYGVWPNKRRSQPGADWRH 515

  Fly   162 G-----RLNAYRYNPFM------DNYLIP-----VDNKPNEVPTLEQLFP------KTIPNMQRK 204
            .     |:.....:||:      |..|.|     :|...|:...||.||.      .|:|...:|
Zfish   516 SSRLHLRVVTLVEHPFVFTRDVDDEGLCPAGQLCLDPLTNDTALLESLFQGLQGANDTVPLEFKK 580

  Fly   205 PLRMCIY----------KDDVRAIFWRQGTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSS 259
                |.|          .:|:...|  ...|:| ||...||...|....:          .:|.|
Zfish   581 ----CCYGYCIDLLEKLAEDMGFDF--DLYIVG-DGKYGAYKNGRWTGLV----------GDLMS 628

  Fly   260 DICFLEVAKEYVDVAMN--IRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGS 322
            ....|.|....::.|.:  |.|..|  |...:...:..|||....|  .|...|..|:
Zfish   629 GAAHLAVTSFSINSARSQVIDFTSP--FFSTSLGILVRTRDTAAPI--GAFMWPLHWS------- 682

  Fly   323 LVWALILVSVLVANVF--CYILKSEVGRVP-------MQLFAGALTMPMTQI--------PPNHS 370
             :|..|.||:.|..||  .|..||..|..|       :..|:.||.:....:        ||...
Zfish   683 -MWLGIFVSLHVTAVFLTLYEWKSPFGMTPRGRNRDRVFSFSSALNVCYAILFGRTAAIKPPKCW 746

  Fly   371 IRLFLI-FWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLT 434
            ...||: .|..|.|...|.:..||.::||.:   ....||..:.....|         |......
Zfish   747 TGRFLMNLWAIFCLFCLSTYTANLAAVMVGE---KTYEQLSGIHDPKLH---------HPSQGFR 799

  Fly   435 LGHKHESRIREQMLEVSDTQMYEMMRNNDI----------------------------RFAYLEK 471
            .|...||. .|..::.|..:|:|.||..:.                            .:|:.:|
Zfish   800 FGTVRESS-AEDYVKKSFPEMHEYMRRYNAPTTPDGIDHLKDDPQKLDAFIMDKALLDYWAHADK 863

  Fly   472 YHIARFQVNSRVHMHLGRPLFHLMNSCLVPFHAVYIVPYGSPYLGFLDSLIRSSHEFGFERYWDR 536
            .:|:.......:.:....||...::.        .:..|.|.  ||:|.|    |:     .|.:
Zfish   864 XYISLLLTGYGIGLKQNSPLTSNISE--------LVSQYKSD--GFMDML----HD-----KWYK 909

  Fly   537 IMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNY 596
            ::...           :|.....|.:.:.::||..:|.:..||:.::.:....||:.|.:
Zfish   910 VVPCG-----------KRSFAVTETLQMGIKHFSGLFVMLCVGVALSLLTTLGEHIVHRW 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	11/50 (22%)
		ANF_receptor	132..452	CDD:279440
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	94/450 (21%)
		Lig_chan	682..941	CDD:278489	58/309 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740