Protein Alignment Ir85a and grin2aa

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 632
• Identity: 108/632 - (17%)
• Similarity: 207/632 - (32%)
• Gaps: 201/632 - (31%)

  Fly    63 EHTGQILKEVTKCDISNQNTPLEAVKDDGILMYMVMITTNISQPLELSLIRKKSAAKHRSHVFLL 127
            |..|.|.:..|.|....:.|.|   ....:..||:.:|.:   ..:||..........:..|.:|
Zfish   305 EEFGDIPEAKTSCYGQMEKTKL---PPSALHKYMMNVTWD---GKDLSFTEDGYQVHPKLVVIVL 363

  Fly   128 VRDAD-TVSDAWMRASFRQFWKIWLLNIVILYWRDGRLNAYRYNPFMDNYLIPVDNKPNEVPTLE 191
            .:|.: .....|...|....:.:|           .|.|::......||:|
Zfish   364 NKDREWEKMGKWENQSLTLKYPVW-----------PRFNSFGDAETDDNHL-------------- 403

  Fly   192 QLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQGTILGTDGLLAAYVAERLNATMMIT----RPHSY 252
                 ||..::.||.   :..::|                      |||..|.|..    |.|..
Zfish   404 -----TIVTLEEKPF---VIVENV----------------------ERLTGTCMRNSVPCRKHIK 438

  Fly   253 NNHNLSSDICFLEVAKEY-VD----VAMNIRF----------------------LVPDTFRKQA- 289
            :|..........:..|.: :|    :|.|::|                      :|.:...|:|
Zfish   439 DNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKKINNVWNGMVGEVVNKKAV 503

  Fly   290 ----ESTVSHTRDD------------LCVIVPKAKTAPTFWNIFRSFGSLVWA-----LILVSVL 333
                ..|::..|.:            :.|:|.::....:.......|.:.||.     |:||:.:
Zfish   504 MAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLLVTAM 568

  Fly   334 VANVFCYILKSEVGRVPMQ----------------LFAGAL---TMPMTQIPPNHSIRLFLIFWL 379
            ...:|.||......|...|                |..|.:   ::|: |.|...:.:..:..|.
Zfish   569 AVFMFEYISPLGFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNSVPV-QNPKGTTSKFIVSVWA 632

  Fly   380 YFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESRIR 444
            :|.::..:::..||.:.|:.:.:   ::|:..|:...:.   .|........|.|:.:....|
Zfish   633 FFAVIFLASYTANLAAFMIQEEF---VDQVTGLSDKKFQ---SPYSYSPPFRFGTVPNGSTER-- 689

  Fly   445 EQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARFQVN-SRVHMHLGRPLFHLMNSCLVPFHA---- 504
                        .:.:|......|:.|||  :..|| :.|.:..|:....:.::.::.:.|
Zfish   690 ------------NIRKNYPDMHQYMVKYH--QTGVNDALVSLKTGKLDAFIYDAAVLNYMAGRDE 740

  Fly   505 -VYIVPYGSPYL----GFLDSLIRSSHEFGFERYWDRIMNSAFIKSGVKVVNRRRGSG------- 557
             ..:|..||.|:    |:..:|.:.|       .|.|.::.|.:    .::    |.|
Zfish   741 GCKLVTIGSGYIFATTGYGIALQKGS-------LWKRPVDLAIL----AII----GDGEMEELEA 790

  Fly   558 --------NDEPVVLKLQ----HFHAVFALWLVGIGMACIVLAWEHL 592
                    |::..|:..|    :...||.:....:|::.|...||||
Zfish   791 QWLTGICHNEKNEVMSSQLDVDNMAGVFYMLATAMGLSLITFVWEHL 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..384	CDD:380601	17/84 (20%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	77/480 (16%)
		NMDAR2_C	836..1460	CDD:463148	2/2 (100%)