DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and grik4

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	811	Identity:	145/811 - (17%)
Similarity:	238/811 - (29%)	Gaps:	320/811 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AILVNLAGTRENHIP-------------------LDLK-----------------KSSIVMVKMS 41
            :|:.|:.|.:|  :|                   |||:                 .||...:..:
Zfish   105 SIISNICGEKE--VPYVKVAPEDILKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICA 167

  Fly    42 QILCKARIKVLFVYFENQTSHEHTGQILKE---VTKCDISNQNTP-LEAVKDD------------ 90
            |..|...::||...|          .|.||   |...|.|...|| |:.::||
Zfish   168 QADCLLNLEVLLRQF----------LISKETLSVRMLDDSQDPTPLLKEIRDDKTATIIVDANAT 222

  Fly    91 ------------GIL-MYMVMITTNISQPLELSLIRKKSAAK-----------HRSHVF------ 125
                        |:| :|...|.|:    ||.||:|....|.           :|:|.|
Zfish   223 MSHVILERASELGMLSVYYTYILTS----LEFSLLRLDDLADQRVNIVGFSVFNRTHPFFQDFVL 283

  Fly   126 -----------------------LLVRDADTVSDAWMRASFRQ----------FWKIW-----LL 152
                                   ||.....||..|....:..|          ..|||     |:
Zfish   284 SLNRSWQENCDHAPFAGTPLSSALLFDAVHTVVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLM 348

  Fly   153 NIVILYWRDGRLNAYRYNP--FMDNYLIPV-DNKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDD 214
            |.:.:...:|......:|.  ...||.:.: .|..:.:..:.|...:...:|:||...:.:
Zfish   349 NYLRMVELEGLTGHIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSLNV---- 409

  Fly   215 VRAIFWRQGTILGTDGLLAAYVAERLNATMMIT----RPH---SYNNHNLSSD-----ICFLEVA 267
                         ||.|        .|.|:.||    .|:   ..|:..|..:     .| :::.
Zfish   410 -------------TDTL--------FNTTLTITTILENPYVMLRANHQELEGNDRYEGFC-VDML 452

  Fly   268 KEYVDVAMNIRF-----LVPD----------TFRKQAESTVSHTRD----DLCVIVPKAKT---- 309
            ||..|:   ::|     ||.|          |:.......:|...|    .|.:...:.|.
Zfish   453 KELADI---LKFKYRIRLVGDGVYGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFS 514

  Fly   310 ------------------APTFWNIFRSFGSLVWALILVSVLVANVFCYI--------------- 341
                              .|.:::....|...||..:|::.|..:...::
Zfish   515 KPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPC 579

  Fly   342 LKSEVGRVPMQL------------FAGALTMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLT 394
            ||   ||..:.:            ..|.:....|..|...|.|.....|..|.|:|.|::..||.
Zfish   580 LK---GRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   395 SMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMM 459
            :.:..|.....|..:..||.               |..:..|..|..... ...:.|..|.|:.|
Zfish   642 AFLTVQRMEVPIESVDDLAD---------------QTAIEYGTMHGGSTM-TFFQNSRYQTYQRM 690

  Fly   460 RNNDIRFAYLEKYHIARFQVNSRVHMHLGRPLFHLMNSCLVPFH------AVYI----------- 507
            .|    |.|.::..:........:...|.....:|:.|.:..::      ...|
Zfish   691 WN----FMYSKQPSVFVKSTEEGIARVLNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYGI 751

  Fly   508 -VPYGSPYLGFLD-SLIRSSHEFGFE----RYWDRIMNSAFIKSGVKVV----NRRRGSGNDEPV 562
             :|.||.|....| :::|...|...|    ::||          |.|..    :|.:|.|
Zfish   752 GMPLGSVYRDEFDLAILRLQEENRLEILKRKWWD----------GGKCPKEEDHRAKGLG----- 801

  Fly   563 VLKLQHFHAVFAL----WLVGIGMACIVLAW 589
               :::...:|.:    .||.|.||.:...|
Zfish   802 ---MENIGGIFVVLVCGLLVAIFMAVLEFVW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	57/310 (18%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	64/386 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740