DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and grid2

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	497	Identity:	90/497 - (18%)
Similarity:	165/497 - (33%)	Gaps:	136/497 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 VPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQGTILGTDGLLAAYVAERLNATMMITRPHS 251
            |..||:.|.....|:..||.:.             ||..:.....||.|:..:..  :.:...|.
Zfish   446 VTVLEEPFVMVSENVLGKPKKY-------------QGFSIDVLDALANYLGFKYE--IYVAPDHK 495

  Fly   252 YNN-------HNLSSDICFLEVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRD----DLCVIVP 305
            |.:       :.|..::.|     :..||.::...:.|     :.||.|..|..    .:.|::.
Zfish   496 YGSQQADGTWNGLIGELVF-----KRADVGLSALTITP-----ERESVVDFTTRYMDYSVGVLLR 550

  Fly   306 KAKTAPTFWNIFRSFGSLVWALILVSVLVANVFCYIL------KSEVGRV-------PMQLFAGA 357
            ||:.....:.....|...:||.|..:||:.....|:|      :..:|.|       .|....|:
Zfish   551 KAERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLNPPRLPMGSVSSTTLYNSMWFVYGS 615

  Fly   358 LTMPMTQIP-PNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIII 421
            ......::| ...:.|:.:..|..|.|::.|::..||.:.:........|..|..||:
Zfish   616 FVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAK------- 673

  Fly   422 RPRHVKHIQHFLTLGHKHESRIREQM---------LEVSDTQMYEMMR-----NNDI-------- 464
                    |..|..|...:|.:.:|:         .:...:||:.|:.     .|::
Zfish   674 --------QTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENNVEESKEGIR 730

  Fly   465 -----RFAYLEKYHIARF-QVNSRVHMHLGRPLFHLMNSCLVPFHAVYIVPYGSPYLGFLDSLIR 523
                 |||::....:..: .:|..     ...|:.:.|:.....:.: .:.:||||.......|.
Zfish   731 KVKYGRFAFVWDAAVLEYVAINDE-----DCSLYTVSNNVADRGYGM-AMQHGSPYRDIFSQRIL 789

  Fly   524 SSHEFGFE-----RYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMA 583
            ...:.|..     ::|.|........   .|..|:.||      .|.:..|..||.:...|:.::
Zfish   790 ELQQNGDMDILKLKWWPRDSPCDLYS---PVGTRKSGS------ALDIHSFAGVFFVLAAGVVLS 845

  Fly   584 CIVLA----W-------------------EHLTHNYNLAVTK 602
            |::..    |                   |||.|..|...|:
Zfish   846 CLIATVETWWTRRKGSRVPSKEDDKEIDLEHLHHRVNSLCTE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386
		ANF_receptor	42..404	CDD:279440
		PBP2_iGluR_delta_2	440..806	CDD:270449	71/405 (18%)
		Lig_chan	568..841	CDD:278489	54/302 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740