DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir85a and CG11155

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	135/758 - (17%)
Similarity:	222/758 - (29%)	Gaps:	309/758 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KVLFVYFEN----QTSHEHTGQILKEVTKCDI-SNQNTP------LEAVKDDGILMYMVMITTNI 103
            ||..:|.|:    ...|..|      .||.:: ..|.:|      |.|::...|  |.:::.||.
  Fly   174 KVAIIYEEDYGLFNLMHSST------ETKAEMYIRQASPDSYRQVLRAIRQKEI--YKIIVDTNP 230

  Fly   104 S-------QPLELSLIRKKSAAKHRSHVFLLVRDADTVSDAWMRASFRQFWKIWLLNIVILYWRD 161
            |       ..|:|.:      ..||.|......|.:|..                       ..|
  Fly   231 SHIKSFFRSILQLQM------NDHRYHYMFTTFDLETYD-----------------------LED 266

  Fly   162 GRLNAYRYNPFMDNYLIPVDNKP-----NEVPTLEQLFPKTI---PNMQRKPLRMCIYKDDVRAI 218
            .|.|:.....|.   |:.||:|.     |::..|:.....||   |.:|.:...|.   |.|.|.
  Fly   267 FRYNSVNITAFR---LVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMF---DSVYAF 325

  Fly   219 --------------------------FWRQGTILG-------TDGLLAA--YVAERLNATMM--- 245
                                      .|..|..|.       ||||...  :|..|.|...:
  Fly   326 ANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIFKLDIL 390

  Fly   246 --------------------ITRPHSYNNHNLSSDICFLEVAKE---YV------DVAMNIRF-- 279
                                |:.|.::.:.|: ::|..:.:.:|   ||      ::..|:||
  Fly   391 KLKQEKIQKVGYWHPDDGVNISDPTAFYDSNI-ANITLVVMTREERPYVMVKEDKNLTGNLRFEG 454

  Fly   280 --------------------LVPDTF--------------------RKQ----AESTVSHTRDDL 300
                                ||||..                    |:.    |..|:::.|:.:
  Fly   455 FCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESV 519

  Fly   301 C------------VIVPKAKTAPTFWNIFRSFGSL---VWALILVSVLVANVFCYILKSEVGRVP 350
            .            ::.....:.||  .:|.....|   :|..:|.:        |||      |.
  Fly   520 IDFTKPFMNLGIGILFKVPTSQPT--RLFSFMNPLAIEIWLYVLAA--------YIL------VS 568

  Fly   351 MQLFAGALTMPM-----------TQIPPNH--------------------------SIRLFLIFW 378
            ..||..|...|.           |.|..|.                          |.|:....|
  Fly   569 FALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCW 633

  Fly   379 LYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESRI 443
            .:|.|:|.|::..||.:.:..:..:..|.....||..           ..|.:....|....:..
  Fly   634 FFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQ-----------TEISYGTLEGGSTMTFF 687

  Fly   444 REQMLEVSDTQMYEMMRNNDIRFAYLEKYH--IARFQVNSRVHMHLGRPLFHLMNSCLVPFHAV- 505
            |:..:.:.. :|:..|.|.... .:::.|.  |.|....|..         .||.|.::.: ||
  Fly   688 RDSKIGIYQ-KMWRYMENRKTA-VFVKTYEDGIKRVMEGSYA---------FLMESTMLDY-AVQ 740

  Fly   506 ------------------YIVPYGSPYLGFLDSLIRSSHEFG-----FERYWDRIMNSAFIKSGV 547
                              ...|.|||:...:...|....|.|     ::::|         |:..
  Fly   741 RDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWW---------KNTG 796

  Fly   548 KVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWE 590
            .|.||...|...:...|.:::...||.:.|.|:.:|.:|..:|
  Fly   797 DVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	52/278 (19%)
		ANF_receptor	61..393	CDD:279440	52/261 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	67/416 (16%)
		Lig_chan	555..829	CDD:278489	57/319 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740