DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and gria4a

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	351	Identity:	61/351 - (17%)
Similarity:	116/351 - (33%)	Gaps:	103/351 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 LCVIVPK-AKTAPTFWNIFRSFGSLVWALILVSVLVANVFCYILKSEVGRV---------PMQLF 354
            :.:::.| .|:.|..::........:|..|:.:.:..:|..::    |.|.         |.:..
Zfish   516 ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL----VSRFSPYEWHTEEPEEGS 576

  Fly   355 AGALTMPMTQIPPNHSIRLFLIF------------------------------WLYFGLLICSAF 389
            .|    |.:..|||.    |.||                              |.:|.|:|.|::
Zfish   577 DG----PPSDQPPNE----FGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSY 633

  Fly   390 KGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQ 454
            ..||.:.:..:..:..|.....||:               |..:..| ..:|...::....|...
Zfish   634 TANLAAFLTVERMVSPIESAEDLAK---------------QTEIAYG-TLDSGSTKEFFRRSKIA 682

  Fly   455 MYEMMRNNDIRFAYLEKYHIARFQVN-----SRVHMHLGRPLFHLMNSCL-------VPFHAVYI 507
            :||.|      ::|::......|...     :||....|:..| |:.|.:       .|...:.:
Zfish   683 VYEKM------WSYMKSAEPTVFTKTTAEGVARVRKSKGKYAF-LLESTMNEYTEQRKPCDTMKV 740

  Fly   508 ------------VPYGSPYLGFLDSLIRSSHEFGFERYWDRIMNSAFIKSGVKVVNRRRGSGNDE 560
                        .|.||.....::..:....|.|   ..|::.|..:...| :...:..||.:..
Zfish   741 GGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAG---VLDKLKNKWWYDKG-ECGPKDSGSKDKS 801

  Fly   561 PVVLKLQHFHAVFALWLVGIGMACIV 586
            ...|.|.:...||.:.:.|:|:|.:|
Zfish   802 SQALSLSNVAGVFYILVGGLGLAMLV 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383
		ANF_receptor	34..375	CDD:279440
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	51/312 (16%)
		Lig_chan	540..821	CDD:278489	54/319 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840