DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and gria3b

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	449	Identity:	82/449 - (18%)
Similarity:	153/449 - (34%)	Gaps:	118/449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TILGTDGLLAAYVAERLNATMMITRPHSYNNH--NLSSDICFLEVAKEYVDVAMNIRFLVPDTFR 286
            ||:.|..:.|.||..:.| .|.:.....|..:  :|:|:|......|..:.:.|:.::...|...
Zfish   414 TIVVTTIMEAPYVMYKKN-HMHLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPET 477

  Fly   287 KQ-----------------AESTVSHTRDD------------LCVIVPK-AKTAPTFWNIFRSFG 321
            |.                 |..|::..|::            :.:::.| .|:.|..::......
Zfish   478 KSWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 542

  Fly   322 SLVWALILVSVLVANVFCYILK---------SEVGRV--------PMQLFA---------GALTM 360
            ..:|..|:.:.:..:|..:::.         .|...|        |...|.         ||...
Zfish   543 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQ 607

  Fly   361 PMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPR 424
            ....|.|.. |.|:....|.:|.|:|.|::..||.:.:..:..:..|.....||:
Zfish   608 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK---------- 662

  Fly   425 HVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARFQVN-----SRVH 484
                 |..:..| ..:|...::....|...:||.|      ::|::....:.|...     :||.
Zfish   663 -----QTEIAYG-TLDSGSTKEFFRRSKIAVYEKM------WSYMKSAEPSVFAKTTPDGVARVR 715

  Fly   485 MHLGRPLFHL---MNSCL---VPFHAVYI------------VPYGSPYLGFLDSLIRSSHEFGFE 531
            ...|:..|.|   ||..:   .|...:.:            .|.||.....::..:...:|.|.
Zfish   716 KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGL- 779

  Fly   532 RYWDRIMNSAFIKSGVKVVNRRRGSG----NDEPVVLKLQHFHAVFALWLVGIGMACIV 586
              .|::.|..:...|      ..|||    .|:...|.|.:...||.:.:.|:|:|.:|
Zfish   780 --LDKLKNKWWYDKG------ECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMV 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141
		ANF_receptor	36..379	CDD:279440
		PBP2_iGluR_AMPA	412..794	CDD:270433	70/411 (17%)
		Lig_chan	544..824	CDD:278489	56/310 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740