DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir85a and GluRIIA

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	71/389 - (18%)
Similarity:	137/389 - (35%)	Gaps:	76/389 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 NHNLSSDICFLEVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFR 318
            :|:....:|.|.:.:....|   :.|.||   ..|...::.|.:..     |:.|....|   ..
  Fly   501 DHHAQIGVCDLTITQMRRSV---VDFTVP---FMQLGISILHYKSP-----PEPKNQFAF---LE 551

  Fly   319 SFGSLVWA-LILVSVLVANVFCYILK----------------SEVGRV-----PMQLFAGALTMP 361
            .|...||. :|...:::...|.:|.:                .|:..:     ...|..|::
  Fly   552 PFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSI--- 613

  Fly   362 MTQ----IPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIR 422
            |.|    :|....:|:....|.:|.|::.|.:..||.:.:....:...|..|..|        |.
  Fly   614 MQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDL--------IE 670

  Fly   423 PRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRN-NDIRFAYLEKYHIARFQVNSRVH-- 484
            ...|    ||.::.....|....:..:....:.:..|:: |...|....|..:||.:.....:
  Fly   671 QDKV----HFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAF 731

  Fly   485 -MHLGRPLFHLMNSC--------LVPFHAVYIVPYGSPYLGFLD-SLIRSSHEFGFERYWDRIMN 539
             |......:::..:|        :...|....||.||.|...|. |:::.|.....::     |.
  Fly   732 LMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQK-----MK 791

  Fly   540 SAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNYNLAVTKR 603
            :.:.|:.....:.......||..:::|   ..||.:...|:.:..|:..:|.|.:..|:||.:|
  Fly   792 NKWWKNHNVTCDSYHEVDGDELSIIEL---GGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEER 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377
		ANF_receptor	46..386	CDD:279440
		PBP2_iGluR_Kainate	426..796	CDD:270432	57/328 (17%)
		Lig_chan	556..828	CDD:278489	50/294 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830