Protein Alignment Ir85a and GRIK3

DIOPT Version :9

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 138/771 - (17%)
• Similarity: 251/771 - (32%)
• Gaps: 251/771 - (32%)

  Fly     3 IQWLK------------HILLLAILVNLAGTREN------HIPLDLKKSSIVMVKMSQILCKARI 49
            :|:||            .::.|..|: :|.:|.|      .:|:|...|..::.:|.:   ....
Human   167 VQYLKWRSATVVYDDSTGLIRLQELI-MAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR---GREF 227

  Fly    50 KVLFVYFENQTSHEHTGQILKEV--------------TKCDISNQNTPLEAVKDDGILMYMVMIT 100
            :::|     ..||....||||:.              |..|:  ....||..:..|:.:....|
Human   228 RIIF-----DCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDL--YALDLEPYRYSGVNLTGFRI- 284

  Fly   101 TNISQPLELSLIRKKS----AAKHRSHVFLL----VRDADTVSDAWMRASFRQFWKIWLLNIV-I 156
            .|:..|...:::.|.|    .|..||...||    :.||..:.||              ::|| :
Human   285 LNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDA--------------VHIVSV 335

  Fly   157 LYWRDGRL----------NAYRYNPFMDNYLIPVDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIY 211
            .|.|..::          .|:|:.....|:   :.....|..|...:|.||........|.:...
Human   336 CYQRAPQMTVNSLQCHRHKAWRFGGRFMNF---IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISL 397

  Fly   212 KDDVRAIFWRQGTILGTDGLLAAYVAE-------------RLNATMMITRPH---------SYNN 254
            |:|.   ..:.|.....|||....||:             .|..|.::..|.         .|.|
Human   398 KEDG---LEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGN 459

  Fly   255 HNLSSDICFLEVAKEYVDV---AMNIRFLVPDTFRKQ----------------------AESTVS 294
            ..... .| :::.||...:   :..||.:....:..|                      |..|::
Human   460 DRFEG-YC-IDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTIT 522

  Fly   295 HTRD------------DLCVIVPKAK-TAPTFWNIFRSFGSLVWALILVSVLVANVFCYILK--- 343
            |.|:            .:.::..|.. |.|:.::........:|..:|::.|..:...:::.
Human   523 HVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFS 587

  Fly   344 -------------SEVGRVPMQLF------AGALTMPMTQIPPNH-SIRLFLIFWLYFGLLICSA 388
                         |||......|.      .|:|....:::.|.. |.|:....|.:|.|:|.|:
Human   588 PYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISS 652

  Fly   389 FKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKH--IQHFLTLGHKHESRIR--EQMLE 449
            :..||.:.:..:.....|:....||:.        ..:::  ::...|:....:|:|.  |:|..
Human   653 YTANLAAFLTVERMESPIDSADDLAKQ--------TKIEYGAVKDGATMTFFKKSKISTFEKMWA 709

  Fly   450 VSDTQMYEMMRNND--IRFAYLEKYHIARFQVNSRVHMHLGRPLFHLMNSCLVPF------HAVY 506
            ...::...:::||:  |:.|....|.:                   ||.|..:.:      :...
Human   710 FMSSKPSALVKNNEEGIQRALTADYAL-------------------LMESTTIEYVTQRNCNLTQ 755

  Fly   507 I------------VPYGSPYLGFLDSLIRSSHE-----FGFERYWDRIMNSAFIKSGVKVVNRRR 554
            |            .|.||||...:...|....|     ...|::|                   |
Human   756 IGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW-------------------R 801

  Fly   555 GSG-----NDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNYNLAVTKRRD 605
            |||     |.|...|.:|....:|.:...|:.::.:|...|.:   |.|..|..|:
Human   802 GSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFV---YKLRKTAERE 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	57/281 (20%)
		ANF_receptor	55..398	CDD:279440	51/259 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	63/415 (15%)
		Lig_chan	564..832	CDD:278489	54/313 (17%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740