DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir85a and GRIK2

DIOPT Version :9

Sequence 1:NP_649833.1 Gene:Ir85a / 41052 FlyBaseID:FBgn0037630 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:746 Identity:132/746 - (17%)
Similarity:247/746 - (33%) Gaps:261/746 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 IPLDLKKSSIVMVKMSQILCKARIKVLFVYFENQTSHEHTGQILKEV--------------TKCD 76
            :|.|.|.:..::.:|.      |.|...|.|:  .|||....|||:.              |..|
Human   204 LPADTKDAKPLLKEMK------RGKEFHVIFD--CSHEMAAGILKQALAMGMMTEYYHYIFTTLD 260

  Fly    77 ISNQNTPLEAVKDDGILM--YMVMIT--TNISQPLE-LSLIRKKSAAKHRSHVF--LLVRDADTV 134
            :...:  :|..:..|:.|  :.::.|  |.:|..:| .|:.|.::..|..|.:.  .:..||..:
Human   261 LFALD--VEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALM 323

  Fly   135 SDA--WMRASFRQF---------------WKI---WLLNIVILYWR--DGRLNAYRYNPFMDNYL 177
            .||  .:..:.:||               |:.   ::..|...:|.  .||:...:.|....::.
Human   324 YDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFD 388

  Fly   178 IPV--------------------------DNKPNEV------------PTLEQ---LFPKTIPNM 201
            :.|                          ..||..:            ..||:   ||.|:    
Human   389 LDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS---- 449

  Fly   202 QRKPL-------RMCIYKDDVRAIFWRQGTILG--------TDGLLAA----------------- 234
             .|||       ..||  |.:|.:    .||||        .||...|                 
Human   450 -DKPLYGNDRFEGYCI--DLLREL----STILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELID 507

  Fly   235 YVAERLNATMMITRPHSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDD 299
            :.|:...|.:.||    |....:      ::.:|.::.:.::|.:..|:                
Human   508 HKADLAVAPLAIT----YVREKV------IDFSKPFMTLGISILYRKPN---------------- 546

  Fly   300 LCVIVPKAKTAPTFWNIFRSFGSLVWALILVSVLVANVFCYIL----------------KSEVGR 348
                    .|.|..::........:|..||::.|..:...:::                .|:|..
Human   547 --------GTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVE 603

  Fly   349 VPMQLF------AGALTMPMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDI 406
            ....|.      .|||....:::.|.. |.|:....|.:|.|:|.|::..||.:.:..:.....|
Human   604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 668

  Fly   407 NQLGALARSHYHIIIRPRHVKH--IQHFLTLGHKHESRI-------------REQMLEVSDTQMY 456
            :....||:.        ..:::  ::...|:....:|:|             |:.:|..|:.:..
Human   669 DSADDLAKQ--------TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGI 725

  Fly   457 EMMRNNDIRFAYLEKYHIARFQVNSRVHM-HLGRPLFHLMNSCLVPFHAVYIV--PYGSPYLGFL 518
            :.:..:|  :|:|.:.....|......:: .:|    .|::|      ..|.|  |.||||...:
Human   726 QRVLTSD--YAFLMESTTIEFVTQRNCNLTQIG----GLIDS------KGYGVGTPMGSPYRDKI 778

  Fly   519 DSLIRSSHEFG-----FERYWDRIMNSAFIKSGVKVVNRRRGSG-----NDEPVVLKLQHFHAVF 573
            ...|....|.|     .|::|                   ||:|     :.|...|.:|:...:|
Human   779 TIAILQLQEEGKLHMMKEKWW-------------------RGNGCPEEESKEASALGVQNIGGIF 824

  Fly   574 ALWLVGIGMACIVLAWEHLTHNYNLAVTKRR 604
            .:...|:.::..|...|.|..:...|..::|
Human   825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR 855

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir85aNP_649833.1 None
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 40/219 (18%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 77/453 (17%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)