DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir85a and GRIK1

DIOPT Version :9

Sequence 1:NP_649833.1 Gene:Ir85a / 41052 FlyBaseID:FBgn0037630 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:720 Identity:131/720 - (18%)
Similarity:226/720 - (31%) Gaps:261/720 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 KVLFVYFENQTSHEHTGQILKEV--------------TKCDISNQNTPLEAVKDDGILMYMVMIT 100
            |..:|.|:  .|||...:|||::              |..|:...:  ||..:..|:.|....: 
Human   223 KEFYVIFD--CSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALD--LELYRYSGVNMTGFRL- 282

  Fly   101 TNISQPLELSLIRKKS----AAKHRSHVFLL----VRDADTVSDAWMRASFRQFWKIWLLNIVIL 157
            .||..|...|:|.|.|    .|..|....||    ..:|..:.||             :..:.|.
Human   283 LNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA-------------VYMVAIA 334

  Fly   158 YWRDGR-----LNAYRYNP------FMDNYLIP-----------VDNKPNEVPTLEQLFPKTIPN 200
            ..|..:     |..:|:.|      ||:  ||.           ..||.|   .|.:.|...|.:
Human   335 SHRASQLTVSSLQCHRHKPWRLGPRFMN--LIKEARWDGLTGHITFNKTN---GLRKDFDLDIIS 394

  Fly   201 MQRKPLRMC-------IYKDDVRAIFWRQGTILG------------TDGLLAAYVAERLNATMMI 246
            ::.:.....       :||...:...|...:.|.            ||.|        .|.|:::
Human   395 LKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSL--------ANRTLIV 451

  Fly   247 T----RPH---------SYNNHNLSSDICFLEVAKEYVDV---AMNIRFLVPD----------TF 285
            |    .|:         .|.|..... .| |::.||..::   ..::: ||||          .:
Human   452 TTILEEPYVMYRKSDKPLYGNDRFEG-YC-LDLLKELSNILGFIYDVK-LVPDGKYGAQNDKGEW 513

  Fly   286 RKQAESTVSHTRDDLCV-----------IVPKAK----------------TAPTFWNIFRSFGSL 323
            ....:..:.| |.||.|           ::..:|                |.|..::........
Human   514 NGMVKELIDH-RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 577

  Fly   324 VWALILVSVLVANVFCYIL----------------KSEVGRVPMQLF------AGALTMPMTQIP 366
            :|..:|::.|..:...:::                .|:|......|.      .|||....:::.
Human   578 IWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 642

  Fly   367 PNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQ 430
            |.. |.|:....|.:|.|:|.|::..||.:.:..:.....|:....||:.           ..|:
Human   643 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ-----------TKIE 696

  Fly   431 H-------FLTLGHKHESRIREQMLE-VSDTQMYEMMRNND--IRFAYLEKYHIARFQVNSRVHM 485
            :       .:|...|.:....|:|.. :|..|...::||:|  |:......|.:           
Human   697 YGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYAL----------- 750

  Fly   486 HLGRPLFHLMNSCLVPF------HAVYI------------VPYGSPYLGFLDSLIRSSHEFG--- 529
                    ||.|..:.:      :...|            .|.||||...:...|....|.|   
Human   751 --------LMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 807

  Fly   530 --FERYWDRIMNSAFIKSGVKVVNRRRGSG-----NDEPVVLKLQHFHAVFALWLVGIGMACIVL 587
              .|::|                   ||:|     |.|...|.:::...:|.:...|:.::..|.
Human   808 MMKEKWW-------------------RGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853

  Fly   588 AWEHL 592
            ..|.:
Human   854 IGEFI 858

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir85aNP_649833.1 None
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 48/229 (21%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 70/421 (17%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)