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Protein Alignment Ir85a and GRIA3

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	496	Identity:	92/496 - (18%)
Similarity:	170/496 - (34%)	Gaps:	119/496 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 YWRDGRLNAY-RYNPFMDNYLIPVDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWR 221
            ||     |.| |:.||.|.. |..|:..:|..|:      .:..:...|..|  ||.:...:...
Human   398 YW-----NEYERFVPFSDQQ-ISNDSASSENRTI------VVTTILESPYVM--YKKNHEQLEGN 448

  Fly   222 ---QGTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSSDI---CFLEVAKEYVDVAMNIRFL 280
               :|..:.....:|.:|  |:...:.|.....|...:..:.|   ...|:.....|:|     :
Human   449 ERYEGYCVDLAYEIAKHV--RIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIA-----V 506

  Fly   281 VPDTFRKQAESTVSHTRD----DLCVIVPK-AKTAPTFWNIFRSFGSLVWALILVSVLVANVFCY 340
            .|.|.....|..:..::.    .:.:::.| .|:.|..::........:|..|:.:.:..:|..:
Human   507 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 571

  Fly   341 IL------------KSEVGRVPMQ---------LF------AGALTMPMTQIPPNH-SIRLFLIF 377
            ::            .:|..|.|..         :|      .||.......|.|.. |.|:....
Human   572 LVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 636

  Fly   378 WLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESR 442
            |.:|.|:|.|::..||.:.:..:..:..|.....||:               |..:..| ..:|.
Human   637 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK---------------QTEIAYG-TLDSG 685

  Fly   443 IREQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARFQVN-----SRVHMHLGRPLFHL---MNSCL 499
            ..::....|...:||.|      ::|::....:.|...     :||....|:..|.|   ||..:
Human   686 STKEFFRRSKIAVYEKM------WSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYI 744

  Fly   500 ---VPFHAVYI------------VPYGSPYLGFLDSLIRSSHEFGFERYWDRIMNSAFIKSGVKV 549
               .|...:.:            .|.||.....::..:...:|.|.   .|::.|..:...|
Human   745 EQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGL---LDKLKNKWWYDKG--- 803

  Fly   550 VNRRRGSG----NDEPVVLKLQHFHAVFALWLVGIGMACIV 586
               ..|||    .|:...|.|.:...||.:.:.|:|:|.:|
Human   804 ---ECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.