DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir85a and Grin2a

DIOPT Version :9

Sequence 1:NP_649833.1 Gene:Ir85a / 41052 FlyBaseID:FBgn0037630 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:732 Identity:143/732 - (19%)
Similarity:250/732 - (34%) Gaps:254/732 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ENHIPLD-----------LKK--SSIVMVKMSQ-----ILCKARIKVL----FVYFENQTSHEHT 65
            :|.|.||           |||  ||::::..|:     ||.:||...|    |.:........:|
  Rat   201 QNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNT 265

  Fly    66 GQILKEVTKCDIS----NQNTPLEAVKDDGILMYMVMITTNISQPLE-LSLI-----------RK 114
            ..|.||.....||    :.:..|||...||    :.::||..|..|| .|.|           .|
  Rat   266 ELIPKEFPSGLISVSYDDWDYSLEARVRDG----LGILTTAASSMLEKFSYIPEAKASCYGQAEK 326

  Fly   115 KSAAKHRSHVFLLVRDADTVSDAW--MRASF-RQFWKIWLLNIVILY-----------WRDGRLN 165
            .....|..|.|:       |:..|  ...|| .:.:::....:||:.           |.:..|:
  Rat   327 PETPLHTLHQFM-------VNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLS 384

  Fly   166 AY-----RYNPFM-----DNYL--IPVDNKPNEV-----PTLEQLFPKTIP-------------- 199
            ..     ||..|.     ||:|  :.::..|..:     |..|.....|:|              
  Rat   385 LRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEG 449

  Fly   200 -NMQRKPLRMC--IYKDDVRAIFWRQGTILGT------------DGLLAAYVAERLNATMMITRP 249
             |:::.....|  |.|...|.:.:.....|.|            :|::...|.:|  |.|.:   
  Rat   450 MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR--AVMAV--- 509

  Fly   250 HSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVP------DTFRKQAESTVSHTRDDLCVIVPKAK 308
                     ..:...|...|.||      |.||      .....::..|||          |.|.
  Rat   510 ---------GSLTINEERSEVVD------FSVPFVETGISVMVSRSNGTVS----------PSAF 549

  Fly   309 TAPTFWNIFRSFGSLVWALILVSVLVAN---VFCYILKSEV--------GRVP----------MQ 352
            ..|        |.:.||.::.|.:|:.:   ||.:...|.|        |:.|          :.
  Rat   550 LEP--------FSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW 606

  Fly   353 LFAGAL---TMPMTQIPPNHSIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALAR 414
            |..|.:   ::|: |.|...:.::.:..|.:|.::..:::..||.:.|:.:.:   ::|:..|:.
  Rat   607 LLWGLVFNNSVPV-QNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF---VDQVTGLSD 667

  Fly   415 SHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARFQV 479
            ..:.   ||             |.:....|...:....|:  ..:|||   :.|:.:| :.||  
  Rat   668 KKFQ---RP-------------HDYSPPFRFGTVPNGSTE--RNIRNN---YPYMHQY-MTRF-- 708

  Fly   480 NSR------VHMHLGRPLFHLMNSCLVPFHA-----VYIVPYGSPYL----GFLDSLIRSSHEFG 529
            |.|      |.:..|:....:.::.::.:.|     ..:|..||.|:    |:..:|.:.|.   
  Rat   709 NQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP--- 770

  Fly   530 FERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPV-------------------VLKLQHFHAVFAL 575
                |.|.::.|.::.        .|.|..|.:                   .|.:.:...||.:
  Rat   771 ----WKRQIDLALLQF--------VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYM 823

  Fly   576 WLVGIGMACIVLAWEHL 592
            ....:.::.|...||||
  Rat   824 LAAAMALSLITFIWEHL 840

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir85aNP_649833.1 None
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 46/201 (23%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 86/479 (18%)
HisJ <458..>541 CDD:223904 18/102 (18%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 55/314 (18%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 3/21 (14%)