DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir85a and Grin3a

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	102/551 - (18%)
Similarity:	176/551 - (31%)	Gaps:	173/551 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 WRDGRL---------NAYRY-------------------NPFM------DNYLIP-----VDNKP 184
            |:.||:         .|.|:                   :||:      |..|.|     :|...
  Rat   484 WQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMT 548

  Fly   185 NEVPTLEQLFPKTIPNMQRKPLRM--CIY----------KDDVRAIF------------WRQGTI 225
            |:...|::||.....:....|::.  |.|          .:|:...|            |:.|..
  Rat   549 NDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHW 613

  Fly   226 LGTDG-LLAAYVAERLNATMMITRPHSYNNHNLSSDICFLEVAKEYVDVAMNIRFLVPDTFRKQA 289
            .|..| ||:.      .|.|.:|   |::.:...|.:               |.|..|  |...:
  Rat   614 TGLVGDLLSG------TANMAVT---SFSINTARSQV---------------IDFTSP--FFSTS 652

  Fly   290 ESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALILVSVLVANVF--CYILKSEVGRVP-- 350
            ...:..|||....|  .|...|..|.        :|..|.|::.:..:|  .|..||..|..|
  Rat   653 LGILVRTRDTAAPI--GAFMWPLHWT--------MWLGIFVALHITAIFLTLYEWKSPFGMTPKG 707

  Fly   351 -----MQLFAGALTMPMTQI--------PPNHSIRLFLI-FWLYFGLLICSAFKGNLTSMMVFQP 401
                 :..|:.||.:....:        ||......||: .|..|.:...|.:..||.::||.:.
  Rat   708 RNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEK 772

  Fly   402 YLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRF 466
            ...:::.            |....:.|.......|...||. .|..:..|..:|:|.||..::..
  Rat   773 IYEELSG------------IHDPKLHHPSQGFRFGTVRESS-AEDYVRQSFPEMHEYMRRYNVPA 824

  Fly   467 ----------------AYLEKYHIARFQVNSRVHMHL---GRPLFHLMNSCLVPFHAVYIVPYGS 512
                            |::....:..::|:......|   |:|.       .:..:.:.:.| .|
  Rat   825 TPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPF-------AIEGYGIGLPP-NS 881

  Fly   513 PYLGFLDSLIRSSHEFGF----ERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVF 573
            |....:..||......||    ...|.:::...           :|.....|.:.:.::||..:|
  Rat   882 PLTSNISELISQYKSHGFMDVLHDKWYKVVPCG-----------KRSFAVTETLQMGIKHFSGLF 935

  Fly   574 ALWLVGIGMACIVLAWEHLTHNYNLAVTKRR 604
            .|..:|.|::.:....||:.|...|...|.:
  Rat   936 VLLCIGFGLSILTTIGEHIVHRLLLPRIKNK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	83/452 (18%)
		Lig_chan	676..942	CDD:278489	53/305 (17%)
		PPP2CB binding site	951..987		5/16 (31%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830