Protein Alignment Ir85a and Grin3b

DIOPT Version :9

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 107/580 - (18%)
• Similarity: 195/580 - (33%)
• Gaps: 183/580 - (31%)

  Fly   138 WMRASFR----QFWKIWLLN---------IVILYWRDGRLN------AYRY-------------- 169
            |:..|.:    :.:|:|.|.         ..:..|:||:|:      |.|.
  Rat   355 WVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRV 419

  Fly   170 -----NPFM------DNYLIP-----VDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIY------- 211
                 :||:      ::...|     :|...|:...|:.||...:.....:.||.|.|
  Rat   420 VTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLL 484

  Fly   212 ---KDDVRAIF-------WRQGTILGTDGLLAAYVAERL--NATMMITRPHSYNNHNLSSDICFL 264
               .:|:...|       .:.|.:  .||.....|.:.|  .|.|.:|   |::.::..|.:
  Rat   485 ERLAEDLAFDFELYIVGDGKYGAL--RDGRWTGLVGDLLAGRAHMAVT---SFSINSARSQV--- 541

  Fly   265 EVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALIL 329
                        :.|..|  |...:...:..|||....|  .|...|..|:        :|..:.
  Rat   542 ------------VDFTSP--FFSTSLGIMVRTRDTASPI--GAFMWPLHWS--------MWVGVF 582

  Fly   330 VSVLVANVF--CYILKSEVGRVP-------MQLFAGALTM---------PMTQIPPNHSIRLFLI 376
            .::.:..:|  .|..:|..|..|       :..::.||.:         ..::.|...:.|..:.
  Rat   583 AALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMN 647

  Fly   377 FWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHES 441
            .|..|.||:.|::..||.::||......:::.            |....:.|.......|...||
  Rat   648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSG------------IHDPKLHHPSQGFRFGTVWES 700

  Fly   442 RIREQMLEVSDTQMYEMMRNNDIRF----------------AYLEKYHIARFQVNSRVHMHL--- 487
            . .|..::.|..:|:..||.:....                |::....:..::|:......|
  Rat   701 S-AEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTV 764

  Fly   488 GRPLFHL--------MNSCLVPFHAVYIVPYGSPYLGFLDSLIRSSHEFGFERYWDRIMNSAFIK 544
            |:| |.:        .||.|....:.:|..|.|.  ||:|.|    |:     .|.::     :.
  Rat   765 GKP-FAIEGYGIGLPQNSPLTSNLSEFISRYKSS--GFIDLL----HD-----KWYKM-----VP 812

  Fly   545 SGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNYNLAVTKRR 604
            .|.:|.      ...|.:.:.:.||..:|.|..:|:|.|.:....||:.  |.|.:.:.|
  Rat   813 CGKRVF------AVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVF--YRLVLPRIR 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	10/49 (20%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	80/450 (18%)
		Lig_chan	576..842	CDD:278489	54/309 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930