DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and gria3a

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	250	Identity:	42/250 - (16%)
Similarity:	87/250 - (34%)	Gaps:	60/250 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TILGTDGLLAAYVAERLNATMMITRPHSYNNH--NLSSDICFLEVAKEYVDVAMNIRFLVPDTFR 286
            ||:.|..:.|.||..:.| .|.:.....|..:  :|:|:|......|..:.:..:.::...|...
Zfish   417 TIVVTTIMEAPYVMYKRN-YMQLEGNDRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPET 480

  Fly   287 KQ-----------------AESTVSHTRDD------------LCVIVPK-AKTAPTFWNIFRSFG 321
            |.                 |..|::..|::            :.:::.| .|:.|..::......
Zfish   481 KTWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 545

  Fly   322 SLVWALILVSVLVANVFCYILK-----------SEVGRVP---------------MQLFAGALTM 360
            ..:|..|:.:.:..:|..:::.           :|..:.|               :....||...
Zfish   546 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQ 610

  Fly   361 PMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALAR 414
            ....|.|.. |.|:....|.:|.|:|.|::..||.:.:..:..:..|.....||:
Zfish   611 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382
		ANF_receptor	39..382	CDD:279440
		PBP2_iGluR_AMPA	415..797	CDD:270433	42/249 (17%)
		Lig_chan	547..810	CDD:278489	21/118 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740