Protein Alignment Ir85a and Grik5

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 772
• Identity: 138/772 - (17%)
• Similarity: 235/772 - (30%)
• Gaps: 293/772 - (37%)

  Fly    33 SSIVMVKMSQILCKARIKVLFVYFENQTSHEHTGQILKE---VTKCDISNQNTP-LEAVKDDGI- 92
            :|::..|..   |..|::.|...|          .|.||   |...|.|...|| |:.::||.:
Mouse   161 ASLICAKAE---CLLRLEELVRGF----------LISKETLSVRMLDDSRDPTPLLKEIRDDKVS 212

  Fly    93 ---------LMYMVM-ITTNISQ--------PLELSLIRKKSAAKHRS---------------HV 124
                     :.::|: ::.|:|.        ||.||.:.:.|.....|               |:
Mouse   213 TIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMTSAFYKYILTTMDFPILHL 277

  Fly   125 FLLVRDADTVSDAWMRASFRQFWKIWL--LNIVILYWRDGRLNAYRY-NP------FMDNYLIPV 180
            ..:|.|:..:....|..:...|:..::  ||   :.||: ...|..| .|      ..|...:.|
Mouse   278 DGIVEDSSNILGFSMFNTSHPFYPEFVRSLN---MSWRE-NCEASTYPGPALSAALMFDAVHVVV 338

  Fly   181 D-----NKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQGTILGT-------DGLLA 233
            .     |:..|:..              ||| .|     ..|..|..||.|..       |||..
Mouse   339 SAVRELNRSQEIGV--------------KPL-AC-----TSANIWPHGTSLMNYLRMVEYDGLTG 383

  Fly   234 AY----VAERLNATMMITRPHS---------YNNHNLSSDICFLEV-----------------AK 268
            ..    ..:|.|.|:.|.....         |:|..|:.:...|::                 ..
Mouse   384 RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILEN 448

  Fly   269 EYV-------DVAMNIRF--LVPDTFRKQAE------------------------------STVS 294
            .||       .::.|.||  ...|..|:.||                              ..::
Mouse   449 PYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELIN 513

  Fly   295 HTRDDLCV-----------IVPKAK----------------TAPTFWNIFRSFGSLVWALILVSV 332
            ..:.||.|           ::..:|                ..|.:::....|...||..:|::.
Mouse   514 RQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAY 578

  Fly   333 LVANVFCYI---------------LKSEVGRVPMQLFAG-ALTMPM-------TQIPPNH-SIRL 373
            |..:...::               |::....:..|...| :|..|:       ::|.|.. |.|.
Mouse   579 LAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRC 643

  Fly   374 FLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALA---RSHYHIIIRPRHVKHIQHFLTL 435
            ....|..|.|:|.|::..||.:.:..|.....:.....||   ...|..|       |....:|
Mouse   644 VSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTI-------HAGSTMT- 700

  Fly   436 GHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKYH-----------IARFQVNSRVHMHLGR 489
                       ..:.|..|.|:.|.|      |::...           |||. :|||....|..
Mouse   701 -----------FFQNSRYQTYQRMWN------YMQSKQPSVFVKSTEEGIARV-LNSRYAFLLES 747

  Fly   490 PL--FHLMNSC-------LVPFHAVYI-VPYGSPY-----LGFLDSLIRSSHEFGFERYWDRIMN 539
            .:  :|...:|       |:......| :|.|||:     |..|.....:..|....::|:
Mouse   748 TMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE---- 808

  Fly   540 SAFIKSGVKVV----NRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHL 592
                  |.:..    :|.:|.|        :::...:|.:.:.|:.:|..|...|.:
Mouse   809 ------GGRCPKEEDHRAKGLG--------MENIGGIFVVLICGLIIAVFVAVMEFI 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	61/299 (20%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:473866	66/396 (17%)