DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and Grik3

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	748	Identity:	129/748 - (17%)
Similarity:	241/748 - (32%)	Gaps:	246/748 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAGTREN------HIPLDLKKSSIVMVKMSQILCKARIKVLFVYFENQTSHEHTGQILKEV---- 72
            :|.:|.|      .:|:|...|..::.:|.:   ....:::|     ..||....||||:.
Mouse   193 MAPSRYNIRLKIRQLPIDSDDSRPLLKEMKR---GREFRIIF-----DCSHTMAAQILKQAMAMG 249

  Fly    73 ----------TKCDISNQNTPLEAVKDDGILMYMVMITTNISQPLELSLIRK------KSAAKHR 121
                      |..|:  ....||..:..|:.:....| .|:..|...:::.|      ::|.:..
Mouse   250 MMTEYYHFIFTTLDL--YALDLEPYRYSGVNLTGFRI-LNVDNPHVSAIVEKWAMERLQAAPRAE 311

  Fly   122 SHVF--LLVRDADTVSDAWMRASFRQFWKIWLLNIV-ILYWRDGRL----------NAYRYNPFM 173
            |.:.  :::.||..:.||              ::|| :.|.|..::          .|:|:....
Mouse   312 SGLLDGVMMTDAALLYDA--------------VHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRF 362

  Fly   174 DNYLIPVDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQGTILGTDGLLAAYVAE 238
            .|:   :.....|..|...:|.||........|.:...|:|.   ..:.|.....|||....||:
Mouse   363 MNF---IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDG---LEKVGVWSPADGLNITEVAK 421

  Fly   239 -------------RLNATMMITRPH---------SYNNHNLSSDICFLEVAKEYVDV---AMNIR 278
                         .|..|.::..|.         .|.|..... .| :::.||...:   :..||
Mouse   422 GRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEG-YC-IDLLKELAHILGFSYEIR 484

  Fly   279 FLVPDTFRKQ----------------------AESTVSHTRD------------DLCVIVPKAK- 308
            .:....:..|                      |..|::|.|:            .:.::..|..
Mouse   485 LVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNG 549

  Fly   309 TAPTFWNIFRSFGSLVWALILVSVLVANVFCYILK----------------SEVGRVPMQLF--- 354
            |.|:.::........:|..:|::.|..:...:::.                |||......|.
Mouse   550 TNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSF 614

  Fly   355 ---AGALTMPMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARS 415
               .|:|....:::.|.. |.|:....|.:|.|:|.|::..||.:.:..:.....|:....||:.
Mouse   615 WFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 679

  Fly   416 HYHIIIRPRHVKH--IQHFLTLGHKHESRIR--EQMLEVSDTQMYEMMRNND--IRFAYLEKYHI 474
                    ..:::  ::...|:....:|:|.  |:|.....::...:::||:  |:......|.:
Mouse   680 --------TKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYAL 736

  Fly   475 ARFQVNSRVHMHLGRPLFHLMNSCLVPFHAVYI----------------------VPYGSPYLGF 517
                               ||.|..:.    ||                      .|.||||...
Mouse   737 -------------------LMESTTIE----YITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDK 778

  Fly   518 LDSLIRSSHE-----FGFERYWDRIMNSAFIKSGVKVVNRRRGSG-----NDEPVVLKLQHFHAV 572
            :...|....|     ...|::|                   ||||     |.|...|.:|....:
Mouse   779 ITIAILQLQEEDKLHIMKEKWW-------------------RGSGCPEEENKEASALGIQKIGGI 824

  Fly   573 FALWLVGIGMACIVLAWEHLTHNYNLAVTKRRD 605
            |.:...|:.::.:|...|.:   |.|..|..|:
Mouse   825 FIVLAAGLVLSVLVAVGEFI---YKLRKTAERE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	48/254 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	63/419 (15%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740