DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and Gria4

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	518	Identity:	89/518 - (17%)
Similarity:	165/518 - (31%)	Gaps:	164/518 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 YWRDGRLNAYRYNPFMDNYLIPVDNKPNEVPTLEQLFPKTIPNMQRKPLRMCIYKDDVRAIFWRQ 222
            ||.|           ||..::..|     .|||                     .:|..||  ..
Mouse   389 YWND-----------MDKLVLIQD-----APTL---------------------GNDTAAI--EN 414

  Fly   223 GTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSSDICF---LEVAKEYVDVAMNIRFLVPD- 283
            .|::.|..:.:.||..:.|..|       :..::.....|.   .|:|| ::.:...|. :|||
Mouse   415 RTVVVTTIMESPYVMYKKNHEM-------FEGNDKYEGYCVDLASEIAK-HIGIKYKIA-IVPDG 470

  Fly   284 -------------------TFRKQ----AESTVSHTRDD------------LCVIVPK-AKTAPT 312
                               .:.|.    |..|::..|::            :.:::.| .|:.|.
Mouse   471 KYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 535

  Fly   313 FWNIFRSFGSLVWALILVSVLVANVFCYILK------------------------SEVGRVPMQL 353
            .::........:|..|:.:.:..:|..:::.                        :|.|......
Mouse   536 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW 600

  Fly   354 FA-GALTMPMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSH 416
            |: ||.......|.|.. |.|:....|.:|.|:|.|::..||.:.:..:..:..|.....||:
Mouse   601 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-- 663

  Fly   417 YHIIIRPRHVKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNNDIRFAYLEKYHIARF---- 477
                         |..:..| ..:|...::....|...:||.|      :.|:.....:.|
Mouse   664 -------------QTEIAYG-TLDSGSTKEFFRRSKIAVYEKM------WTYMRSAEPSVFTRTT 708

  Fly   478 -QVNSRVHMHLGRPLFHL---MNSCL---VPFHAVYI------------VPYGSPYLGFLDSLIR 523
             :..:||....|:..|.|   ||..:   .|...:.:            .|.||.....::..:.
Mouse   709 AEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVL 773

  Fly   524 SSHEFGFERYWDRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIV 586
            ...|.|   ..|::.|..:...|  ....:.....|:...|.|.:...||.:.:.|:|:|.:|
Mouse   774 KLSEAG---VLDKLKNKWWYDKG--ECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLV 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	5/21 (24%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	68/416 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740