DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir85a and Gria2

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	373	Identity:	69/373 - (18%)
Similarity:	129/373 - (34%)	Gaps:	94/373 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 DVAMNIRFLVPDTFRKQAESTVSHTRD----DLCVIVPK-AKTAPTFWNIFRSFGSLVWALILVS 331
            |:|     :.|.|.....|..:..::.    .:.:::.| .|:.|..::........:|..|:.:
Mouse   494 DIA-----IAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553

  Fly   332 VLVANVFCYILK------------------------SEVGRVPMQLFA-GALTMPMTQIPPNH-S 370
            .:..:|..:::.                        :|.|......|: ||.......|.|.. |
Mouse   554 YIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLS 618

  Fly   371 IRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTL 435
            .|:....|.:|.|:|.|::..||.:.:..:..:..|.....|:          :..:.....|..
Mouse   619 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS----------KQTEIAYGTLDS 673

  Fly   436 GHKHESRIREQMLEVSDTQMYEMMRNNDIR-FAYLEKYHIARFQVNSRVHMHLGRPLFHLMNSCL 499
            |...|. .|...:.|.| :|:..||:.:.. |.......:||.:.:...:.:|   |...||..:
Mouse   674 GSTKEF-FRRSKIAVFD-KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL---LESTMNEYI 733

  Fly   500 VPFHAVYIVPYGSPYLGFLD-----------SLIRSSHEFGFERYWDRIMNSAFIK---SGV--K 548
            ........:..|    |.||           |.:|:.            :|.|.:|   .||  |
Mouse   734 EQRKPCDTMKVG----GNLDSKGYGIATPKGSSLRTP------------VNLAVLKLSEQGVLDK 782

  Fly   549 VVNR---------RRGSGNDEPV-VLKLQHFHAVFALWLVGIGMACIV 586
            :.|:         .:.||:.|.. .|.|.:...||.:.:.|:|:|.:|
Mouse   783 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	58/335 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740