DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir85a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	511	Identity:	99/511 - (19%)
Similarity:	167/511 - (32%)	Gaps:	143/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 NPFM------DNYLIP-----VDNKPNEVPTLEQLFPKTIPNMQRKPLRM--CIY---------- 211
            :||:      |..|.|     :|...|:..||:.||.....:....|::.  |.|
Human   523 HPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKI 587

  Fly   212 KDDVRAIF------------WRQGTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSSDICFL 264
            .:|:...|            |:.|...|..|.|.     |..|.|.:|   |::.:...|.:
Human   588 AEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLL-----RGTAHMAVT---SFSINTARSQV--- 641

  Fly   265 EVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALIL 329
                        |.|..|  |...:...:..|||....|  .|...|..|.        :|..|.
Human   642 ------------IDFTSP--FFSTSLGILVRTRDTAAPI--GAFMWPLHWT--------MWLGIF 682

  Fly   330 VSVLVANVF--CYILKSEVGRVP-------MQLFAGALTMPMTQI--------PPNHSIRLFLI- 376
            |::.:..||  .|..||..|..|       :..|:.||.:....:        ||......||:
Human   683 VALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMN 747

  Fly   377 FWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHES 441
            .|..|.:...|.:..||.::||.:....:::.            |....:.|.......|...||
Human   748 LWAIFCMFCLSTYTANLAAVMVGEKIYEELSG------------IHDPKLHHPSQGFRFGTVRES 800

  Fly   442 RIREQMLEVSDTQMYEMMRNNDIRF----------------AYLEKYHIARFQVNSRVHMHL--- 487
            . .|..:..|..:|:|.||..::..                |::....:..::|:......|
Human   801 S-AEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTV 864

  Fly   488 GRPLFHLMNSCLVPFHAVYIVPYGSPYLGFLDSLIRSSHEFGF----ERYWDRIMNSAFIKSGVK 548
            |:|.       .:..:.:.:.| .||....:..||......||    ...|.|::...
Human   865 GKPF-------AIEGYGIGLPP-NSPLTANISELISQYKSHGFMDMLHDKWYRVVPCG------- 914

  Fly   549 VVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNYNLAVTKRR 604
                :|.....|.:.:.::||..:|.|..:|.|::.:....||:.:...|...|.:
Human   915 ----KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	85/440 (19%)
		Lig_chan	676..942	CDD:278489	55/305 (18%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		4/16 (25%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830