Protein Alignment Ir85a and GRIN3A

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_597702.2
• Gene: GRIN3A / 116443
• HGNCID: 16767
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 99/511 - (19%)
• Similarity: 167/511 - (32%)
• Gaps: 143/511 - (27%)

  Fly   170 NPFM------DNYLIP-----VDNKPNEVPTLEQLFPKTIPNMQRKPLRM--CIY---------- 211
            :||:      |..|.|     :|...|:..||:.||.....:....|::.  |.|
Human   523 HPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKI 587

  Fly   212 KDDVRAIF------------WRQGTILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSSDICFL 264
            .:|:...|            |:.|...|..|.|.     |..|.|.:|   |::.:...|.:
Human   588 AEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLL-----RGTAHMAVT---SFSINTARSQV--- 641

  Fly   265 EVAKEYVDVAMNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGSLVWALIL 329
                        |.|..|  |...:...:..|||....|  .|...|..|.        :|..|.
Human   642 ------------IDFTSP--FFSTSLGILVRTRDTAAPI--GAFMWPLHWT--------MWLGIF 682

  Fly   330 VSVLVANVF--CYILKSEVGRVP-------MQLFAGALTMPMTQI--------PPNHSIRLFLI- 376
            |::.:..||  .|..||..|..|       :..|:.||.:....:        ||......||:
Human   683 VALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMN 747

  Fly   377 FWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKHIQHFLTLGHKHES 441
            .|..|.:...|.:..||.::||.:....:::.            |....:.|.......|...||
Human   748 LWAIFCMFCLSTYTANLAAVMVGEKIYEELSG------------IHDPKLHHPSQGFRFGTVRES 800

  Fly   442 RIREQMLEVSDTQMYEMMRNNDIRF----------------AYLEKYHIARFQVNSRVHMHL--- 487
            . .|..:..|..:|:|.||..::..                |::....:..::|:......|
Human   801 S-AEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTV 864

  Fly   488 GRPLFHLMNSCLVPFHAVYIVPYGSPYLGFLDSLIRSSHEFGF----ERYWDRIMNSAFIKSGVK 548
            |:|.       .:..:.:.:.| .||....:..||......||    ...|.|::...
Human   865 GKPF-------AIEGYGIGLPP-NSPLTANISELISQYKSHGFMDMLHDKWYRVVPCG------- 914

  Fly   549 VVNRRRGSGNDEPVVLKLQHFHAVFALWLVGIGMACIVLAWEHLTHNYNLAVTKRR 604
                :|.....|.:.:.::||..:|.|..:|.|::.:....||:.:...|...|.:
Human   915 ----KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	85/440 (19%)
		Lig_chan	674..941	CDD:459656	56/306 (18%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		4/16 (25%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1062..1095