Protein Alignment CG8223 and HIF1

DIOPT Version :9

• Sequence 1: NP_001246993.1
• Gene: CG8223 / 41045
• FlyBaseID: FBgn0037624
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_013078.1
• Gene: HIF1 / 850638
• SGDID: S000003945
• Length: 385
• Species: Saccharomyces cerevisiae
• Alignment Length: 451
• Identity: 82/451 - (18%)
• Similarity: 163/451 - (36%)
• Gaps: 118/451 - (26%)

  Fly    49 EQERAEKILKGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELAD-ELGQPLLLYAKALI 112
            :.||..:|  .|:|.:|       |.:.|||....|......: .|.|.| ||   ..::|:|:.
Yeast    21 DMERQVQI--AKDLLAQ-------KKFLEAAKRCQQTLDSLPK-DGLLPDPEL---FTIFAQAVY 72

  Fly   113 AMALDENKVIDVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDTKEAANGASSSNGKELD---- 173
            .|.:              .:..::..|...:.:||:..:.|.:...:.:||...:...:.:
Yeast    73 NMEV--------------QNSGNLFGDALLAGDDGSGSESESEPESDVSNGEEGNENGQTEIPNS 123

  Fly   174 -TIKEGSDEADSTGEAEQAQSDEKPSKKVPTGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCS 237
             ..:...:|.|.||:                 ||...|.:.|.|   :::|..:....|...:..
Yeast   124 RMFQFDQEEEDLTGD-----------------VDSGDSEDSGEG---SEEEEENVEKEEERLALH 168

  Fly   238 NGA--APAVEEEPEEEEGVSGSLQLAWEILEAAAQIFSRQGLSGLPYLAEVQTELANIEFENGIL 300
            ..|  :||.|.:.|.|:                              :::::....:|.|||.:.
Yeast   169 ELANFSPANEHDDEIED------------------------------VSQLRKSGFHIYFENDLY 203

  Fly   301 EAAREDYEKALKIHGELPTRNRRALAE-LHYKIGLTY-LMQQLNKEG----------ATALRQSS 353
            |.|.:...:||.:.|. ||.:.::|.| ...:||..| ||..:.:|.          ..||....
Yeast   204 ENALDLLAQALMLLGR-PTADGQSLTENSRLRIGDVYILMGDIEREAEMFSRAIHHYLKALGYYK 267

  Fly   354 VLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEI-EEMQAQTIAEVRAALDSYI--KP 415
            .|            :|:|:....::..|....:.|..:.:: .:.:.:.....:|.|:.::  :|
Yeast   268 TL------------KPAEQVTEKVIQAEFLVCDALRWVDQVPAKDKLKRFKHAKALLEKHMTTRP 320

  Fly   416 MSSGDAAAASSSSSSSANGAASSSSSSSKGAAAASSSTIS-SSSAKP----TDITHLIKRK 471
            ..|....|..:......:....:....||...:..:::|. .:..||    .|::.|:|:|
Yeast   321 KDSELQQARLAQIQDDIDEVQENQQHGSKRPLSQPTTSIGFPALEKPLGDFNDLSQLVKKK 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8223	NP_001246993.1	TPR_12	281..352	CDD:290160	21/82 (26%)
		TPR repeat	283..313	CDD:276809	8/29 (28%)
		TPR repeat	326..351	CDD:276809	9/36 (25%)
HIF1	NP_013078.1	SHNi-TPR	237..273	CDD:402238	8/47 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900