DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8223 and AT4G37210

DIOPT Version :9

Sequence 1:	NP_001246993.1	Gene:	CG8223 / 41045	FlyBaseID:	FBgn0037624	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_568019.1	Gene:	AT4G37210 / 829875	AraportID:	AT4G37210	Length:	492	Species:	Arabidopsis thaliana

Alignment Length:	549	Identity:	113/549 - (20%)
Similarity:	208/549 - (37%)	Gaps:	138/549 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAEAEAIVTTATADVSSPSKTV---------AVEPVAADTT-------PDNAPAVSTEGSGKAEQ 50
            ||...:::.|.|...:..::|:         .||.|....|       .:|..|..:..:...::
plant     7 SASEASVIQTLTEPATEIAQTLEPNLASIEATVESVVQGGTESTCNNDANNNNAADSAATEVCDE 71

  Fly    51 ERAEKILKGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMA 115
            ||.:.:...:||..:||.......:.||.|..|:..::....||||..|.......|..||:|.|
plant    72 EREKTLEFAEELTEKGSVFLKENDFAEAVDCFSRALEIRVAHYGELDAECINAYYRYGLALLAKA 136

  Fly   116 LDENKVIDVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDTKEAANGASSSNGKELDTIKEGSD 180
                                    :.|:...|...|:|.:..:|::||.|.:     .::..|..
plant   137 ------------------------QAEADPLGNMPKKEGEVQQESSNGESLA-----PSVVSGDP 172

  Fly   181 EADSTGEAEQAQSDEKPSKKVPTGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCSNGAAPAVE 245
            |...:.                      |...|.||....:|       ||   .|.:......:
plant   173 ERQGSS----------------------SGQEGSGGKDQGED-------GE---DCQDDDLSDAD 205

  Fly   246 EEPEEEEGVSGSLQLAWEILEAAAQIFSRQGLSGLPYLAEVQTELANIEFENGILEAAREDYEKA 310
            .:.:|:|   ..|.:||::|:.|..|..:|....:..: ::...||.:..|...:|::..||:.|
plant   206 GDADEDE---SDLDMAWKMLDIARVITDKQSTETMEKV-DILCSLAEVSLEREDIESSLSDYKNA 266

  Fly   311 LKIHGELPTRNRRALAELHYKI------------GLTYL----------MQQLNKE--GATALRQ 351
            |.|...|...:.|..|||:::|            .:.|.          |::|:.|  ||:....
plant   267 LSILERLVEPDSRRTAELNFRICICLETGCQPKEAIPYCQKALLICKARMERLSNEIKGASGSAT 331

  Fly   352 SSVLIE-----EEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQAQTIAEVRAALDS 411
            ||.:.|     ::.:.:...|:.:......:.||....:::..|:::::: ||:...:|.|.|..
plant   332 SSTVSEIDEGIQQSSNVPYIDKSASDKEVEIGDLAGLAEDLEKKLEDLKQ-QAENPKQVLAELMG 395

  Fly   412 YI--KPMSSGDAAAASSSSSSSANGAASSS----------SSSSKGAAAASSSTISSSSAKPTDI 464
            .:  ||.:|.....|::..|||..|..:::          |::..|||...::         :.:
plant   396 MVSAKPNASDKVVPAAAEMSSSRMGTVNTNFGKDLESPTVSTAHTGAAGGGAA---------SGV 451

  Fly   465 THL------IKRKKPEDPSSEAEALCSPA 487
            |||      :||......|.|:.|...||
plant   452 THLGVVGRGVKRVLMNTTSIESSASKKPA 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8223	NP_001246993.1	TPR_12	281..352	CDD:290160	21/94 (22%)
		TPR repeat	283..313	CDD:276809	8/29 (28%)
		TPR repeat	326..351	CDD:276809	10/48 (21%)
AT4G37210	NP_568019.1	TPR repeat	80..116	CDD:276809	9/35 (26%)
		TPR_1	80..110	CDD:395414	8/29 (28%)
		TPR_12	83..140	CDD:315987	17/80 (21%)
		TPR repeat	240..268	CDD:276809	7/28 (25%)
		TPR_12	242..309	CDD:315987	16/66 (24%)
		TPR repeat	273..311	CDD:276809	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176629at2759
OrthoFinder	1	1.000	-	-		FOG0005069
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103724
Panther	1	1.100	-	-	LDO	PTHR15081
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.870