DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8223 and Nasp

DIOPT Version :9

Sequence 1:	NP_001246993.1	Gene:	CG8223 / 41045	FlyBaseID:	FBgn0037624	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_058057.3	Gene:	Nasp / 50927	MGIID:	1355328	Length:	773	Species:	Mus musculus

Alignment Length:	748	Identity:	152/748 - (20%)
Similarity:	248/748 - (33%)	Gaps:	299/748 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ADVSSPSKTVAVEPVAADTTPDNAPAVSTEGSGKAEQERAEKILKGKELFSQGSRNFLVKSYDEA 78
            |..|:.:..:|.|.|:||...| |||.||...   :.|..:...:.|:|...|.::.::.....|
Mouse     2 ATESTAAAAIAAELVSADKIED-APAPSTSAD---KMESLDVDSEAKKLLGLGQKHLVMGDIPAA 62

  Fly    79 ADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVI---------------DVPDEA 128
            .:...:...|..:.|||.|:|.|:....|.|:|:.:|..||.|:               ...||:
Mouse    63 VNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDES 127

  Fly   129 ADDDDEDVDDD--EE--ESAEDGAAKKEEKK---------------------------------- 155
            ..:::::||::  ||  |...|...:||.||
Mouse   128 LVENNDNVDEEAREELREQVYDAMGEKEAKKAEGKSLTKPETDKEQESEVEKGGREDMDISEPEE 192

  Fly   156 ------------------DTKEAA---------------------------NGASSSNGKELDTI 175
                              :.||||                           :||...|.:..:|:
Mouse   193 KLQETVEPTSKQLTESSEEAKEAAIPGLNEDEVASGKTEQESLCTEKGKSISGAYVQNKEFRETV 257

  Fly   176 KEGSD------------------EADSTG--------EAE---QAQS----DEKPSKKVPTGVDE 207
            :||.:                  .|:..|        |||   |.:|    .|:|..:|.|...|
Mouse   258 EEGEEIISLEKKPKETSEDQPIRAAEKQGTLMKVVEIEAEIDPQVKSADVGGEEPKDQVATSESE 322

  Fly   208 VSSS------------------------------------NGG---GGAAVNDD--ERPSTSNGE 231
            :..:                                    |.|   |.:.|.|.  ..|.||...
Mouse   323 LGKAVLMELSGQDVEASPVVAAEAGAEVSEKPGQEITVIPNNGPVVGQSTVGDQTPSEPQTSAER 387

  Fly   232 VTASCSNGAAPAVEEE--PEEEE-------------GVS-------------------------- 255
            :|.:....:...|:.|  ||:||             ||.
Mouse   388 LTETKDGSSVEEVKAELVPEQEEAMLPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANEETQE 452

  Fly   256 ----------------------------------------------GSLQLAWEILEAAAQIFSR 274
                                                          |:|:|||::|:.|..||.|
Mouse   453 RDEQMKEGEETEGSEEEDRENDKAEETPNESVLEKKSLQENEEEEIGNLELAWDMLDLAKIIFKR 517

  Fly   275 QGLSGLP-YLAEVQTELANIEFENGILEAAREDYEKALKIHGELPTRNRRALAELHYKIGLTYLM 338
            |...... |.|:...:|..:..|:.....|.|:::..|.:..:....:.|.|||.||::||.|..
Mouse   518 QETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGY 582

  Fly   339 QQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQAQTIA 403
            .....|......:|..:||:.:|.:          ...|.:.|.:..|...:|:|::|:    :.
Mouse   583 NSQYDEAVAQFGKSIDVIEKRMAVL----------HEQMKEAEGSFTEYEKEIEELKEL----LP 633

  Fly   404 EVRAALDSYIKPMSSGDAA--------AASSSSSSSANGAASSSS--SSSKGAAAASSSTISSSS 458
            |:|..::...:...||:.|        ..||:|..:.:||.:|.|  :|.|....||||..
Mouse   634 EIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNC---- 694

  Fly   459 AKPTDITHLI-KRKKPEDPSSEAEALCSPAKRA 490
              .|||:||: |::|||:.|...:    .||:|
Mouse   695 --VTDISHLVRKKRKPEEESPRKD----DAKKA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8223	NP_001246993.1	TPR_12	281..352	CDD:290160	17/71 (24%)
		TPR repeat	283..313	CDD:276809	6/29 (21%)
		TPR repeat	326..351	CDD:276809	8/24 (33%)
Nasp	NP_058057.3	TPR 1. /evidence=ECO:0000255	43..76		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..244		16/128 (13%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	116..127		1/10 (10%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	210..242		4/31 (13%)
		TPR 2. /evidence=ECO:0000255	237..270		6/32 (19%)
		2A1904	<250..505	CDD:273344	36/254 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..284		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..321		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..493		17/143 (12%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	455..498		0/42 (0%)
		TPR repeat	497..520	CDD:276809	11/22 (50%)
		TPR_12	526..602	CDD:315987	19/75 (25%)
		SHNi-TPR	528..565	CDD:371109	6/36 (17%)
		TPR 3. /evidence=ECO:0000255	528..561		6/32 (19%)
		TPR repeat	528..556	CDD:276809	5/27 (19%)
		TPR repeat	561..599	CDD:276809	11/37 (30%)
		TPR 4. /evidence=ECO:0000255	570..603		11/32 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..773		18/49 (37%)
		Nuclear localization signal. /evidence=ECO:0000255	702..708		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834472
Domainoid	1	1.000	69	1.000	Domainoid score	I9663
eggNOG	1	0.900	-	-		E1_KOG4563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005069
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103724
Panther	1	1.100	-	-	LDO	PTHR15081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730