DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8223 and NASP

DIOPT Version :9

Sequence 1:NP_001246993.1 Gene:CG8223 / 41045 FlyBaseID:FBgn0037624 Length:492 Species:Drosophila melanogaster
Sequence 2:XP_005270945.1 Gene:NASP / 4678 HGNCID:7644 Length:790 Species:Homo sapiens


Alignment Length:715 Identity:141/715 - (19%)
Similarity:228/715 - (31%) Gaps:303/715 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 KGKELFSQGSRNFLVKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVI 122
            :.|:|...|.::.::.....|.:...:...|..:.|||.|:|.|:....|.|:|:.:|..||.|:
Human    44 EAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVL 108

  Fly   123 ---------------DVPDEAADDDDEDVDDD--EE--ESAEDGAAKKEEKKDTKEAA------- 161
                           ...||:..::::::|::  ||  |...|...:|||.|.|::.:       
Human   109 GNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETD 173

  Fly   162 ---NGASSSNGKE------------------LDTIKEGSDEAD-------------STGEAEQAQ 192
               :......|:|                  ||.:.|.|:||.             ::|:.||..
Human   174 KEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEV 238

  Fly   193 SD---------------------------------EKPS-------------------------- 198
            .|                                 |||.                          
Human   239 PDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLD 303

  Fly   199 ---KKVPTGVDE-----VSSSNGGGGAA----VNDDERPSTSNGEVTASCSNGAA---------- 241
               |.|..|.||     |:|.|..|.|.    |..:..|:..:.|||...:..:|          
Human   304 PTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEK 368

  Fly   242 -----------------------------------------------------PAVEE------- 246
                                                                 |:.||       
Human   369 PGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEE 433

  Fly   247 -----------------------------------------EPEEEEGVS--------------- 255
                                                     |.||.||..               
Human   434 SEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 498

  Fly   256 ----------------GSLQLAWEILEAAAQIFSRQGLSGLP-YLAEVQTELANIEFENGILEAA 303
                            |:|:|||::|:.|..||.||...... |.|:...:|..:..|:.....|
Human   499 SVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQA 563

  Fly   304 REDYEKALKIHGELPTRNRRALAELHYKIGLTYLMQQLNKEGATALRQSSVLIEEEIA----EIK 364
            .|:::..|.:..:....:.|.|||.||::||.|.......|......:|..:||..:|    ::|
Human   564 VEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK 628

  Fly   365 GKDEPSERDRNNMLDLEETKQEILAKIQEIEEMQ-AQTIAEVRAALDSYIKPMSSGDAAAASSSS 428
            ..:..|...:..:.:|:|...||..||::.:|.| :..:||:  ||.:.:         ..||:|
Human   629 EAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAEL--ALKATL---------VESSTS 682

  Fly   429 SSSANGAASSSS--SSSKGAAAASSSTISSSSAKPTDITHLI-KRKKPEDPSSEAEALCSPAKRA 490
            ..:..|..||.|  :|.|....||||..      .|||:||: |::|||:.|...:    .||:|
Human   683 GFTPGGGGSSVSMIASRKPTDGASSSNC------VTDISHLVRKKRKPEEESPRKD----DAKKA 737

  Fly   491  490
            Human   738  737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8223NP_001246993.1 TPR_12 281..352 CDD:290160 17/71 (24%)
TPR repeat 283..313 CDD:276809 6/29 (21%)
TPR repeat 326..351 CDD:276809 8/24 (33%)
NASPXP_005270945.1 2A1904 <218..518 CDD:273344 32/299 (11%)
TPR repeat 513..536 CDD:276809 11/22 (50%)
TPR_12 542..618 CDD:315987 19/75 (25%)
SHNi-TPR 544..581 CDD:402238 6/36 (17%)
TPR repeat 544..572 CDD:276809 5/27 (19%)
TPR repeat 577..615 CDD:276809 11/37 (30%)
TPR repeat 619..642 CDD:276809 3/22 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144330
Domainoid 1 1.000 74 1.000 Domainoid score I9225
eggNOG 1 0.900 - - E1_KOG4563
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 91 1.000 Inparanoid score I5112
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1176629at2759
OrthoFinder 1 1.000 - - FOG0005069
OrthoInspector 1 1.000 - - oto89121
orthoMCL 1 0.900 - - OOG6_103724
Panther 1 1.100 - - LDO PTHR15081
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.790

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