DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8223 and Nasp

DIOPT Version :9

Sequence 1:	NP_001246993.1	Gene:	CG8223 / 41045	FlyBaseID:	FBgn0037624	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001005543.1	Gene:	Nasp / 298441	RGDID:	1359609	Length:	776	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	153/757 - (20%)
Similarity:	244/757 - (32%)	Gaps:	308/757 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AIVTTATADVSSPSKTVAVEPVAADTTPDNAPAVSTEGSGKAEQERAEKILKGKELFSQGSRNFL 71
            |..:||||       .:|.|.|:||...| |||.||...   :.|..:...:.|:|...|.::.:
  Rat     2 ATESTATA-------AIAAELVSADKVED-APAPSTSAD---KMESLDVDSEAKKLLGLGQKHLV 55

  Fly    72 VKSYDEAADELSQVCQLYEEVYGELADELGQPLLLYAKALIAMALDENKVI-------------- 122
            :.....|.:...:...|..:.|||.|:|.|:....|.|:|:.:|..||.|:
  Rat    56 MGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120

  Fly   123 -DVPDEAADDDDEDVDDD--EE--ESAEDGAAKKEEKKDTKEAANGASSSNGKELDTIKEGSDEA 182
             ...||:..:::::||::  ||  |...|...:||.||...::.....:...:|.:..|.|.::.
  Rat   121 EKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDM 185

  Fly   183 DSTGEAEQAQ-------------SDEKPSKKVP-------------------------TGV---- 205
            |.:..||:.|             |:|.....:|                         :||
  Rat   186 DISEPAEKLQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQN 250

  Fly   206 ---------------------------------------------------DEVSSSNGGG---- 215
                                                               .||.|.:.||
  Rat   251 KEFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPK 315

  Fly   216 ----------GAAV---------------------NDDERPS------TSNGEVTASCSNG---- 239
                      |.||                     ...|:|.      .:||.|....|.|
  Rat   316 DQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTP 380

  Fly   240 --------------------------------AAPAVEE-------------------------- 246
                                            |.|.|||
  Rat   381 SEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFK 445

  Fly   247 ---------------EPEEEEGVS-------------------------------GSLQLAWEIL 265
                           |.||.||..                               |:|:|||::|
  Rat   446 IAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWDML 510

  Fly   266 EAAAQIFSRQGLSGLP-YLAEVQTELANIEFENGILEAAREDYEKALKIHGELPTRNRRALAELH 329
            :.|..||.||...... |.|:...:|..:..|:.....|.|:::..|.:..:....:.|.|||.|
  Rat   511 DLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETH 575

  Fly   330 YKIGLTYLMQQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNNMLDLEETKQEILAKIQEI 394
            |::||.|.......|......:|..:||:.:|.:          ...|.:.|.:..|...:|:|:
  Rat   576 YQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVL----------LEQMKEAEGSFTEYEKEIEEL 630

  Fly   395 EEMQAQTIAEVRAALDSYIKPMSSGDAA--------AASSSSSSSANGAASSSS--SSSKGAAAA 449
            :|:    :.|:|..::...:...||:.|        ..||:|..:.:||.:|.|  :|.|....|
  Rat   631 KEL----LPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGA 691

  Fly   450 SSSTISSSSAKPTDITHLI-KRKKPEDPSSEAEALCSPAKRA 490
            |||..      .|||:||: |::|||:.|...:    .||:|
  Rat   692 SSSNC------VTDISHLVRKKRKPEEESPRKD----DAKKA 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8223	NP_001246993.1	TPR_12	281..352	CDD:290160	17/71 (24%)
		TPR repeat	283..313	CDD:276809	6/29 (21%)
		TPR repeat	326..351	CDD:276809	8/24 (33%)
Nasp	NP_001005543.1	TPR 1. /evidence=ECO:0000255	43..76		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..241		22/125 (18%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	116..127		1/10 (10%)
		MDN1	<130..493	CDD:227596	47/362 (13%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	210..242		2/31 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..289		0/32 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..497		17/151 (11%)
		Histone-binding. /evidence=ECO:0000250\|UniProtKB:P49321	457..500		5/42 (12%)
		TPR repeat	499..522	CDD:276809	11/22 (50%)
		TPR_12	528..604	CDD:315987	19/75 (25%)
		SHNi-TPR	530..567	CDD:402238	6/36 (17%)
		TPR 2. /evidence=ECO:0000255	530..563		6/32 (19%)
		TPR repeat	530..558	CDD:276809	5/27 (19%)
		TPR repeat	563..601	CDD:276809	11/37 (30%)
		TPR 3. /evidence=ECO:0000255	572..605		11/32 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..776		18/49 (37%)
		Nuclear localization signal. /evidence=ECO:0000255	704..710		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338050
Domainoid	1	1.000	74	1.000	Domainoid score	I9000
eggNOG	1	0.900	-	-		E1_KOG4563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176629at2759
OrthoFinder	1	1.000	-	-		FOG0005069
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103724
Panther	1	1.100	-	-	LDO	PTHR15081
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710