Protein Alignment CG8223 and nasp-2

DIOPT Version :9

• Sequence 1: NP_001246993.1
• Gene: CG8223 / 41045
• FlyBaseID: FBgn0037624
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_506298.1
• Gene: nasp-2 / 179810
• WormBaseID: WBGene00008218
• Length: 582
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 132/559 - (23%)
• Similarity: 228/559 - (40%)
• Gaps: 142/559 - (25%)

  Fly     7 AIVTTATADVSSPSKTVA--VEPVA-ADT------TPDNAPAVSTE---------GSGKAEQERA 53
            |.....||..:||::..|  |:.|| |.|      |....|||..:         |:...:.|.:
 Worm    46 ATTNEKTASENSPTEAAASDVKDVAEASTGAQETNTSSETPAVVEDEKASMEVSIGTSIEDSETS 110

  Fly    54 EKILKG---------KELFSQGSRNFLVKS------------YDEAADELSQVCQLYEEVYGELA 97
            :|.::|         :|:..:..|..|.::            :|:|.|.||....:..||:|:..
 Worm   111 QKEIEGELVVPENPVEEISPEQKRKSLSENIIAGRRFMRTDVFDKAVDVLSVAASIAAEVFGDAH 175

  Fly    98 DELGQPLLLYAKALIAMALDENKVI-----DVPDEAADDDDEDVDDDEEESAEDGAAKKEEKKDT 157
            ::..:...||.|||:.:...|::|:     |||..|  :.:|:|.|...|:.||  ..::|:.:.
 Worm   176 EDTFEANFLYGKALLEVGKLEDRVLANALTDVPKMA--EGEEEVQDGIVENPED--VPQDERAEI 236

  Fly   158 KEAANGASSSNGKELDTI------------KEGSDEADSTGEAEQAQSDEK---------PSKKV 201
            |:....|.....:|.:|:            :|.|.|.|.....||.|.:|:         |::.|
 Worm   237 KQKVEEALGVASEEPETVADEAVKTEQKEAEEDSVEKDVENSDEQNQEEEEVVENEATVDPTEDV 301

  Fly   202 P-TGVDEVSSSNGGGGAAVNDDERPSTSNGEVTASCSNGAAPAVEEEPEEEEGVSGSLQLAWEIL 265
            . .||:||:.....|..|..|.|                    .||:.|.|:..:.|::||||:|
 Worm   302 EMEGVEEVNDEKEVGQTAEVDGE--------------------AEEDDEAEDDEADSMKLAWELL 346

  Fly   266 EA--------AAQIFSRQGLSGLPY------LAEVQTELANIEFENGI----LEAAREDYEKALK 312
            |.        ||.:.:...:.|...      ||:|.|.|.    |:||    .|.|::|..:|:.
 Worm   347 ETSRCIADKKAASLAAESTVDGEAIKMWKLNLADVLTSLG----EHGIADSKYEQAQKDLTEAIS 407

  Fly   313 IHG-ELPTRNRRALAELHYKIGLTYLMQQLNKEGATALRQSSVLIEEEIAEIKGKDEPSERDRNN 376
            |.. .||..: |.:|...:.:...:....|.::.|.....:..::..:..|:|.:.|...
 Worm   408 IQTVHLPATS-RVIANTTHLLAKAFSSDSLFEQAAAHFNDTKNILIAKSEELKKQLETVS----- 466

  Fly   377 MLDLEETKQEILAKIQEIEEMQAQTIAEVRAALDSYIKPMSSGDAAAASSSSSSSANGAASSSSS 441
                ::.|.:|.::|:|::.:    |.|    ||::|.     ||.|    |:.......|.:..
 Worm   467 ----DDAKSDIQSEIKELDGI----IPE----LDAFIV-----DARA----SAEQTEKLKSDAKK 510

  Fly   442 SSKGAAAASSSTISSSSAKPTDITHLIKRKKPEDPSSEA 480
            ..:||||..:.....:.|  |||:.:::|......|.||
 Worm   511 ELEGAAAMLAKVADVTEA--TDISSMVRRPTKRPASEEA 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8223	NP_001246993.1	TPR_12	281..352	CDD:290160	19/81 (23%)
		TPR repeat	283..313	CDD:276809	12/33 (36%)
		TPR repeat	326..351	CDD:276809	3/24 (13%)
nasp-2	NP_506298.1	TPR_12	376..453	CDD:315987	19/81 (23%)
		SHNi-TPR	379..416	CDD:371109	14/40 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49312
OrthoDB	1	1.010	-	-		D1176629at2759
OrthoFinder	1	1.000	-	-		FOG0005069
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103724
Panther	1	1.100	-	-	O	PTHR15081
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.950