Protein Alignment M1BP and ZNF646

DIOPT Version :10

• Sequence 1: NP_649825.1
• Gene: M1BP / 41042
• FlyBaseID: FBgn0037621
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_055514.3
• Gene: ZNF646 / 9726
• HGNCID: 29004
• Length: 1832
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 105/496 - (21%)
• Similarity: 156/496 - (31%)
• Gaps: 168/496 - (33%)

  Fly    20 ASNKRSPKLFERSNTKMIDNIE-ALTGLRLENYGCLPDQICECCSMELASAVKLRERCIAAQREL 83
            |:..|||.| :.|..::::.:: .:..|....||    .||.||.........|...
Human   925 AAPARSPPL-QLSEAELLNQLQREVEALDSAGYG----HICGCCGQTYDDLGSLERH-------- 976

  Fly    84 LLGLTEEQRQGISAFYRAAVMG--------------EDIVQTVK-------------TPDDDEVY 121
                .:.|..|.:|....:.:|              ||||.:|.             ||..|.:.
Human   977 ----HQSQSSGTTADKAPSPLGVAGDAMEMVVDSVLEDIVNSVSGEGGDAKSQEGAGTPLGDSLC 1037

  Fly   122 ATYQEIVLE-EPK---------------EEIDDTKVE-------------YDN--TYYEVAEGH- 154
            ....|.:|| :|:               ..::..|:.             |.|  .|......|
Human  1038 IQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHP 1102

  Fly   155 --AGEDDAASLIEEADYDS----------------IMAEDEEQQQTLE-LDEDTELIVGDVNDAY 200
              .|.:.....|.||...|                .|||:...|..:| |.|:.::
Human  1103 RCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMAEEGPGQAEVEKLQEELKV--------- 1158

  Fly   201 VYDSDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTG-GVYICEQCGNHIKGRM 264
              :..:|||   .|.::.:  |...||...:.|:.:......:...:. ..:.||.||...|...
Human  1159 --EPLEEVA---RVKEEVW--EETTVKGEEIEPRLETAEKGCQTEASSERPFSCEVCGRSYKHAG 1216

  Fly   265 AFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTH 329
            :...|.:.|: ...|||:.|...|.....||.|.|.|...|.|.|..||:.|........|:|.|
Human  1217 SLINHRQSHQ-TGHFGCQACSKGFSNLMSLKNHRRIHADPRRFRCSECGKAFRLRKQLASHQRVH 1280

  Fly   330 -------------TNERPYVCGTCG---------------------------KAFTTGYILKNHM 354
                         ..:||:.||.||                           |.::....||:|.
Human  1281 MERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQ 1345

  Fly   355 LIHSGER----------AYRCELCDKSF----MLPTHLSTH 381
            .:||..|          |.||.||.:||    .|..||..|
Human  1346 RLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLREH 1386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	14/64 (22%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		COG5048	276..>331	CDD:227381	19/67 (28%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:463886	10/23 (43%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	324..346	CDD:463886	10/61 (16%)
		C2H2 Zn finger	337..357	CDD:275368	8/46 (17%)
		zf-H2C2_2	350..372	CDD:463886	11/31 (35%)
		C2H2 Zn finger	365..383	CDD:275368	9/21 (43%)
ZNF646	NP_055514.3	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..47
		C2H2 Zn finger	50..70	CDD:275368
		zf-C2H2	75..97	CDD:395048
		C2H2 Zn finger	77..97	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..200
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..346
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	646..663	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..810
		C2H2 Zn finger	823..843	CDD:275368
		C2H2 Zn finger	850..870	CDD:275368
		C2H2 Zn finger	883..901	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..931		2/5 (40%)
		C2H2 Zn finger	1054..1074	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1081..1101	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1103..1148		9/44 (20%)
		C2H2 Zn finger	1205..1225	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1232..1252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1260..1280	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1274..1294		3/19 (16%)
		C2H2 Zn finger	1301..1321	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1328..1348	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1366..1386	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1377..1481		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1509..1529
		C2H2 Zn finger	1533..1552	CDD:275368
		C2H2 Zn finger	1559..1579	CDD:275368
		C2H2 Zn finger	1587..1611	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1606..1672
		C2H2 Zn finger	1679..1699	CDD:275368
		C2H2 Zn finger	1706..1726	CDD:275368
		C2H2 Zn finger	1734..1754	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1781..1832