DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M1BP and CRZ1

DIOPT Version :9

Sequence 1:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	267	Identity:	67/267 - (25%)
Similarity:	102/267 - (38%)	Gaps:	54/267 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 TPDDD-EVYATYQEIVLEE----PKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIM 173
            :||:. :..:..:|.:||.    |..|.|:.:..|||.                  .:..|::|.
Yeast   429 SPDEKAKSISANREKLLEMADLLPSSENDNNRERYDND------------------SKTSYNTIN 475

  Fly   174 AE--DEEQQQTLELDEDTELIVGDVNDAYVYDSDDEVAVLDNVLDDEYEHENIVVKKCSL---PP 233
            :.  :|:......|....::..|.||             :.|.|||..:...|::...||   ..
Yeast   476 SSNFNEDNNNNNLLTSKPKIESGIVN-------------IKNELDDTSKDLGILLDIDSLGQFEQ 527

  Fly   234 KPKVRSDDARRRGTGGVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHM 298
            |...::||.......|.:..::..|..|    .:......:....|.|::|..:|.....||.|:
Yeast   528 KVGFKNDDNHENNDNGTFSVKKNDNLEK----LDSVTNNRKNPANFACDVCGKKFTRPYNLKSHL 588

  Fly   299 RKHTGERPFACKYCGRCFTDYTTRVKHERTHTNERPYVCG---------TCGKAFTTGYILKNHM 354
            |.||.||||.|..||:.|.....|.:||..||.::.||||         .|||.|.....|..|.
Yeast   589 RTHTNERPFICSICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHF 653

  Fly   355 LIHSGER 361
            ...||.|
Yeast   654 KTESGRR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		COG5048	276..>331	CDD:227381	22/54 (41%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	13/23 (57%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..346	CDD:290200	12/30 (40%)
		C2H2 Zn finger	337..357	CDD:275368	8/28 (29%)
		zf-H2C2_2	350..372	CDD:290200	5/12 (42%)
		C2H2 Zn finger	365..383	CDD:275368
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	51/222 (23%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	599..619	CDD:275368	7/19 (37%)
		C2H2 Zn finger	627..655	CDD:275368	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100